Macrophages play a key role in tissue repair and regeneration

PeerJ. 2022 Sep 29:10:e14053. doi: 10.7717/peerj.14053. eCollection 2022.

Abstract

Tissue regeneration after body injury has always been a complex problem to resolve for mammals. In adult mammals, the repair process after tissue injury is often accompanied by continuous and extensive fibrosis, which leads to scars. This process has been shown to severely hinder regeneration. Macrophages, as widely distributed innate immune cells, not only play an important role in various pathological processes, but also participate in the repair process before tissue regeneration and coordinate the regeneration process after repair. This review will discuss the various forms and indispensability of macrophages involved in repair and regeneration, and how macrophages play a role in the repair and regeneration of different tissues.

Keywords: Cytokine; Polarization; Regeneration; Tissue repair; Macrophage.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cicatrix / pathology
  • Fibrosis
  • Macrophages*
  • Mammals
  • Wound Healing*

Grants and funding

This work was supported by the National Natural Science Foundation of P.R.China (No. 31670996). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.