1 From the Department of Anaesthesiology, Intensive Care, Emergency Care and Pain Medicine, University of Turku (AK, JK), the Division of Perioperative Services, Intensive Care Medicine and Pain Management (AK, JK), the Heart Centre, Turku University Hospital (JG, AR, EV, TV, TOK), the Division of Medicine (JG, AR, EV, TV, TOK), Medicity Research Facilities, University of Turku, Turku, Finland (JJ, MH).