Strategic use of organoids and organs-on-chip as biomimetic tools

Anderson K Santos; Sérgio Scalzo; Raysa T V de Souza; Pedro H G Santana; Bruno L Marques; Lucas F Oliveira; Daniel M Filho; Alexandre Hiroaki Kihara; Helton da Costa Santiago; Ricardo C Parreira; Alexander Birbrair; Henning Ulrich; Rodrigo R Resende

doi:10.1016/j.semcdb.2022.09.010

Strategic use of organoids and organs-on-chip as biomimetic tools

Semin Cell Dev Biol. 2023 Jul 30:144:3-10. doi: 10.1016/j.semcdb.2022.09.010. Epub 2022 Sep 30.

Affiliations

¹ Department of Pediatrics, Cellular and Molecular Physiology, Yale School of Medicine, New Haven, CT, USA.
² Departamento de Fisiologia e Biofísica, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
³ Centro Universitário de Mineiros, UNIFIMES, Mineiros, GO, Brazil.
⁴ Departamento de Farmacologia, Instituto de Ciências Biológicas, Universidade Federal de Goiás, Goiânia, GO, Brazil.
⁵ Departamento de Fisiologia, Instituto de Ciências Biológicas, Universidade Federal do Triângulo Mineiro, Uberaba, MG, Brazil.
⁶ Departamento de Fisiologia, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, São Paulo, Brazil.
⁷ Centro de Matemática, Computação e Cognição, Universidade Federal do ABC, São Bernardo do Campo, SP, Brazil.
⁸ Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
⁹ Departmento de Patologia, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil; Department of Dermatology, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA; Department of Radiology, Columbia University Medical Center, New York, NY, USA.
¹⁰ Departmento de Bioquímica, Instituto de Química, Universidade de São Paulo, São Paulo, Brazil.
¹¹ Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil; Instituto Nanocell, Divinópolis, Brazil. Electronic address: rrresende@hotmail.com.

PMID: 36192310
DOI: 10.1016/j.semcdb.2022.09.010

Abstract

Organoid development and organ-on-a-chip are technologies based on differentiating stem cells, forming 3D multicellular structures resembling organs and tissues in vivo. Hence, both can be strategically used for disease modeling, drug screening, and host-pathogen studies. In this context, this review highlights the significant advancements in the area, providing technical approaches to organoids and organ-on-a-chip that best imitate in vivo physiology.

Keywords: Bioengineering; Bioprinting; Organ development; Organ-On-Chip; Organoid.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Biomimetics*
Microphysiological Systems
Organoids*
Stem Cells