A role for the claustrum in cognitive control

Maxwell B Madden; Brent W Stewart; Michael G White; Samuel R Krimmel; Houman Qadir; Frederick S Barrett; David A Seminowicz; Brian N Mathur

doi:10.1016/j.tics.2022.09.006

A role for the claustrum in cognitive control

Trends Cogn Sci. 2022 Dec;26(12):1133-1152. doi: 10.1016/j.tics.2022.09.006. Epub 2022 Sep 30.

Authors

Maxwell B Madden¹, Brent W Stewart², Michael G White¹, Samuel R Krimmel³, Houman Qadir¹, Frederick S Barrett⁴, David A Seminowicz⁵, Brian N Mathur⁶

Affiliations

¹ Department of Pharmacology, School of Medicine, University of Maryland, Baltimore, MD 21201, USA.
² Department of Pharmacology, School of Medicine, University of Maryland, Baltimore, MD 21201, USA; Department of Neural and Pain Sciences, School of Dentistry, University of Maryland, Baltimore, MD 21201, USA; Center to Advance Chronic Pain Research, University of Maryland, Baltimore, MD 21201, USA.
³ Department of Neural and Pain Sciences, School of Dentistry, University of Maryland, Baltimore, MD 21201, USA; Center to Advance Chronic Pain Research, University of Maryland, Baltimore, MD 21201, USA.
⁴ Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA; Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA; Department of Psychological and Brain Sciences, Johns Hopkins University, Baltimore, MD 21224, USA.
⁵ Department of Neural and Pain Sciences, School of Dentistry, University of Maryland, Baltimore, MD 21201, USA; Center to Advance Chronic Pain Research, University of Maryland, Baltimore, MD 21201, USA; Department of Medical Biophysics, Schulich School of Medicine & Dentistry, University of Western Ontario, London, Ontario, Canada.
⁶ Department of Pharmacology, School of Medicine, University of Maryland, Baltimore, MD 21201, USA; Department of Psychiatry, School of Medicine, University of Maryland, Baltimore, MD 21201, USA. Electronic address: bmathur@som.umaryland.edu.

Abstract

Early hypotheses of claustrum function were fueled by neuroanatomical data and yielded suggestions that the claustrum is involved in processes ranging from salience detection to multisensory integration for perceptual binding. While these hypotheses spurred useful investigations, incompatibilities inherent in these views must be reconciled to further conceptualize claustrum function amid a wealth of new data. Here, we review the varied models of claustrum function and synthesize them with developments in the field to produce a novel functional model: network instantiation in cognitive control (NICC). This model proposes that frontal cortices direct the claustrum to flexibly instantiate cortical networks to subserve cognitive control. We present literature support for this model and provide testable predictions arising from this conceptual framework.

Keywords: attention; cognition; cognitive network; cortex; cortical network; working memory.

Publication types

Review
Research Support, N.I.H., Extramural

MeSH terms

Basal Ganglia
Claustrum*
Cognition
Frontal Lobe
Humans
Neural Pathways

Abstract

Publication types

MeSH terms

Grants and funding