OMMR: Co-registration toolbox of OPM-MEG and MRI

Fuzhi Cao; Nan An; Weinan Xu; Wenli Wang; Wen Li; Chunhui Wang; Yanfei Yang; Min Xiang; Yang Gao; Xiaolin Ning

doi:10.3389/fnins.2022.984036

OMMR: Co-registration toolbox of OPM-MEG and MRI

Front Neurosci. 2022 Sep 15:16:984036. doi: 10.3389/fnins.2022.984036. eCollection 2022.

Authors

Fuzhi Cao^{1

2}, Nan An^{1

2}, Weinan Xu^{1

2}, Wenli Wang^{1

2}, Wen Li^{1

2}, Chunhui Wang^{1

2}, Yanfei Yang^{1

2}, Min Xiang^{2

3}, Yang Gao^{2

4}, Xiaolin Ning^{2

3}

Affiliations

¹ Zhejiang Provincial Key Laboratory of Ultra-Weak Magnetic-Field Space and Applied Technology, Hangzhou Innovation Institute, Beihang University, Hangzhou, China.
² Key Laboratory of Ultra-Weak Magnetic Field Measurement Technology, Ministry of Education, School of Instrumentation and Optoelectronic Engineering, Beihang University, Beijing, China.
³ Research Institute for Frontier Science, Beihang University, Beijing, China.
⁴ Beijing Academy of Quantum Information Sciences, Beijing, China.

Abstract

Magnetoencephalography (MEG) based on optically pumped magnetometers (OPM-MEG) has shown better flexibility in sensor configuration compared with the conventional superconducting quantum interference devices-based MEG system while being better suited for all-age groups. However, this flexibility presents challenges for the co-registration of MEG and magnetic resonance imaging (MRI), hindering adoption. This study presents a toolbox called OMMR, developed in Matlab, that facilitates the co-registration step for researchers and clinicians. OMMR integrates the co-registration methods of using the electromagnetic digitization system and two types of optical scanners (the structural-light and laser scanner). As the first open-source co-registration toolbox specifically for OPM-MEG, the toolbox aims to standardize the co-registration process and set the ground for future applications of OPM-MEG.

Keywords: OPM-MEG; co-registration; electromagnetic digitization system; magnetoencephalography (MEG); optical scanner.