Near-Infrared Turn-On Fluorescent Probe for Aqueous Fluoride Ion Detection and Cell Imaging

Yan Liu; Yaping Zhou; Hongyu Li; Jie Gao; Mingyan Yang; Zeli Yuan; Xinmin Li

doi:10.1021/acsomega.2c03875

Near-Infrared Turn-On Fluorescent Probe for Aqueous Fluoride Ion Detection and Cell Imaging

ACS Omega. 2022 Sep 12;7(38):34317-34325. doi: 10.1021/acsomega.2c03875. eCollection 2022 Sep 27.

Authors

Yan Liu^{1

2

3}, Yaping Zhou¹, Hongyu Li^{1

2

3}, Jie Gao^{1

2

3}, Mingyan Yang^{1

2

3}, Zeli Yuan^{1

2

3}, Xinmin Li^{1

2

3}

Affiliations

¹ College of Pharmacy, Zunyi Medical University, Zunyi, Guizhou 563003, China.
² Key Laboratory of Basic Pharmacology of Ministry of Education and Joint International Research Laboratory of Ethnomedicine of Ministry of Education, Zunyi Medical University, Zunyi, Guizhou 563000, China.
³ Guizhou International Scientific and Technological Cooperation Base for Medical Photo-Theranostics Technology and Innovative Drug Development, Zunyi, Guizhou 563003, China.

Abstract

Fluoride ions are one of the most essential anions in the human body and have been implicated in various pathological and physiological processes. The detection of fluoride ions in aqueous solution, as well as the imaging of fluoride ions in living cells, remains a challenge. We herein report a BODIPY-based fluorescent probe employing a pinacol borate group as the recognition moiety for the detection of fluoride ions in aqueous solutions. This probe shows high selectivity and sensitivity to fluoride ions with a significant near-infrared fluorescence turn-on response. In addition, this probe was successfully employed in fluorescence bioimaging of fluoride ions in the human cervical cancer cell and mouse mammary cancer cell, demonstrating its good cell permeability and stability under physiological conditions.