Ultrasound optical tomography (UOT) is a hybrid imaging modality based on interaction between ultrasound and light, with a potential to extend optical imaging capabilities in biological tissues to depths of several centimeters. Several methods have been developed to detect the UOT signal. To better understand their potential for deep tissue imaging, we present a theoretical contrast-to-noise comparison between the spectral hole burning, single-shot off-axis holography, speckle contrast, and photorefractive detection methods for UOT. Our results indicate that spectral hole burning filters have the potential to reach the largest imaging depths. We find that digital off-axis holography and photorefractive detection can have good contrast-to-noise ratio at significant depths. The speckle contrast method has a smaller penetration depth comparatively.
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