Cellular senescence and abdominal aortic aneurysm: From pathogenesis to therapeutics

Ding Wang; Xinyu Hao; Longyuan Jia; Yuchen Jing; Bo Jiang; Shijie Xin

doi:10.3389/fcvm.2022.999465

Cellular senescence and abdominal aortic aneurysm: From pathogenesis to therapeutics

Front Cardiovasc Med. 2022 Sep 14:9:999465. doi: 10.3389/fcvm.2022.999465. eCollection 2022.

Authors

Ding Wang^{1

2}, Xinyu Hao^{1

2}, Longyuan Jia^{1

2}, Yuchen Jing^{1

2}, Bo Jiang^{1

2}, Shijie Xin^{1

2}

Affiliations

¹ Department of Vascular Surgery, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning, China.
² Key Laboratory of Pathogenesis, Prevention and Therapeutics of Aortic Aneurysm, Shenyang, Liaoning, China.

Abstract

As China's population enters the aging stage, the threat of abdominal aortic aneurysm (AAA) mainly in elderly patients is becoming more and more serious. It is of great clinical significance to study the pathogenesis of AAA and explore potential therapeutic targets. The purpose of this paper is to analyze the pathogenesis of AAA from the perspective of cellular senescence: on the basis of clear evidence of cellular senescence in aneurysm wall, we actively elucidate specific molecular and regulatory pathways, and to explore the targeted drugs related to senescence and senescent cells eliminate measures, eventually improve the health of patients with AAA and prolong the life of human beings.

Keywords: abdominal aortic aneurysm; cellular senescence; longevity; pathogenesis; therapeutics.

Publication types

Review