Small extracellular vesicles: multi-faceted tools for leukemia immune evasion in vivo

Ernesto Gargiulo; Elodie Viry; Etienne Moussay; Jerome Paggetti

doi:10.1080/2162402X.2022.2127507

Small extracellular vesicles: multi-faceted tools for leukemia immune evasion in vivo

Oncoimmunology. 2022 Sep 27;11(1):2127507. doi: 10.1080/2162402X.2022.2127507. eCollection 2022.

Authors

Ernesto Gargiulo^{1

2

3}, Elodie Viry¹, Etienne Moussay¹, Jerome Paggetti¹

Affiliations

¹ Tumor Stroma Interactions Group, Department of Cancer Research, Luxembourg Institute of Health, Luxembourg, Luxembourg.
² Department of Hematology, CLL Laboratory, Rigshospitalet, Copenhagen, Denmark.
³ PERSIMUNE, Department of Infectious Diseases, Rigshospitalet, Copenhagen, Denmark.

Abstract

Recently, small extracellular vesicles (sEVs) secreted in vivo from chronic lymphocytic leukemia (CLL) preclinical murine models were characterized. Leukemia microenvironment sEV (LME-sEVs) selectively target CD8⁺ T-cells, inducing exhaustion and hampering anti-tumor immune response. Additionally, a sEV-related gene expression correlated with patient treatment-free survival, overall survival and clinical parameters.

Keywords: CLL; Small extracellular vesicles; exosomes; sEV-based biomarkers; tumor immune escape; tumor microenvironment.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
CD8-Positive T-Lymphocytes
Extracellular Vesicles* / metabolism
Humans
Immune Evasion
Leukemia, Lymphocytic, Chronic, B-Cell* / diagnosis
Leukemia, Lymphocytic, Chronic, B-Cell* / metabolism
Mice
Tumor Microenvironment

Grants and funding

This work was supported by grants from the Luxembourg National Research Fund (FNR) and Fondation Cancer, Luxembourg to EG, EM and JP (PRIDE15/10675146/CANBIO, INTER/DFG/16/11509946, C20/BM/14582635 and C20/BM/14592342) and from Fonds National de la Recherche Scientifique (FNRS)-Télévie to EV (7.4509.20).