Coating bacteria for anti-tumor therapy

Jiahui Wang; Ning Guo; Weiliang Hou; Huanlong Qin

doi:10.3389/fbioe.2022.1020020

Coating bacteria for anti-tumor therapy

Front Bioeng Biotechnol. 2022 Sep 15:10:1020020. doi: 10.3389/fbioe.2022.1020020. eCollection 2022.

Authors

Jiahui Wang¹, Ning Guo¹, Weiliang Hou^{1

2}, Huanlong Qin¹

Affiliations

¹ Department of Gastrointestinal Surgery, Shanghai Tenth People's Hospital, Tongji University, Shanghai, China.
² Shanghai Key Laboratory for Nucleic Acid Chemistry and Nanomedicine, Institute of Molecular Medicine, Renji Hospital School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

Abstract

Therapeutic bacteria have shown great potential on anti-tumor therapy. Compared with traditional therapeutic strategy, living bacteria present unique advantages. Bacteria show high targeting and great colonization ability in tumor microenvironment with hypoxic and nutritious conditions. Bacterial-medicated antitumor therapy has been successfully applied on mouse models, but the low therapeutic effect and biosafe limit its application on clinical treatment. With the development of material science, coating living bacteria with suitable materials has received widespread attention to achieve synergetic therapy on tumor. In this review, we summarize various materials for coating living bacteria in cancer therapy and envision the opportunities and challenges of bacteria-medicated antitumor therapy.

Keywords: bacteria; coating; materials; tumor targeting; tumor therapy.

Publication types

Review