Perspectives of lipid metabolism reprogramming in head and neck squamous cell carcinoma: An overview

Xiangwan Miao; Beilei Wang; Kaili Chen; Rui Ding; Jichang Wu; Yi Pan; Peilin Ji; Bin Ye; Mingliang Xiang

doi:10.3389/fonc.2022.1008361

Perspectives of lipid metabolism reprogramming in head and neck squamous cell carcinoma: An overview

Front Oncol. 2022 Sep 16:12:1008361. doi: 10.3389/fonc.2022.1008361. eCollection 2022.

Authors

Xiangwan Miao^{1

2

3}, Beilei Wang^{1

2

3}, Kaili Chen^{1

2

3}, Rui Ding^{1

2

3}, Jichang Wu^{1

2

3}, Yi Pan^{1

2

3}, Peilin Ji^{1

2

3}, Bin Ye^{1

2

3}, Mingliang Xiang^{1

2

3}

Affiliations

¹ Department of Otolaryngology & Head and Neck Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
² Shanghai Key Laboratory of Translational Medicine on Ear and Nose Diseases, Shanghai, China.
³ Ear Institute, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Abstract

Recent studies showed that lipid metabolism reprogramming contributes to tumorigenicity and malignancy by interfering energy production, membrane formation, and signal transduction in cancers. HNSCCs are highly reliant on aerobic glycolysis and glutamine metabolism. However, the mechanisms underlying lipid metabolism reprogramming in HNSCCs remains obscure. The present review summarizes and discusses the "vital" cellular signaling roles of the lipid metabolism reprogramming in HNSCCs. We also address the differences between HNSCCs regions caused by anatomical heterogeneity. We enumerate these recent findings into our current understanding of lipid metabolism reprogramming in HNSCCs and introduce the new and exciting therapeutic implications of targeting the lipid metabolism.

Keywords: HNSCCs; lipid catabolism; lipid metabolism reprogramming; lipid synthesis; lipid uptake.

Publication types

Review