Osteoporosis and sarcopenia are associated with each other and reduced IGF1 levels are a risk for both diseases in the very old elderly

Ryosuke Hata; Kana Miyamoto; Yukiko Abe; Takashi Sasaki; Yuko Oguma; Takayuki Tajima; Yasumichi Arai; Morio Matsumoto; Masaya Nakamura; Arihiko Kanaji; Takeshi Miyamoto

doi:10.1016/j.bone.2022.116570

Osteoporosis and sarcopenia are associated with each other and reduced IGF1 levels are a risk for both diseases in the very old elderly

Bone. 2023 Jan:166:116570. doi: 10.1016/j.bone.2022.116570. Epub 2022 Sep 29.

Authors

Affiliations

¹ Department of Orthopedic Surgery, Keio University School of Medicine, 35 Shinano-machi, Shinjuku-ku, Tokyo 160-8582, Japan.
² Department of Orthopedic Surgery, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto 860-8556, Japan.
³ Centre for Supercentenarian Medical Research, Keio University School of Medicine, 35 Shinano-machi, Shinjuku-ku, Tokyo 160-8582, Japan.
⁴ Sports Medicine Research Center, Keio University, 4-1-1 Hiyoshi, Kohoku-ku, Yokohama, Kanagawa 223-0061, Japan; Graduate School of Health Management, Keio University, 4-1-1 Hiyoshi, Kohoku-ku, Yokohama, Kanagawa 223-0061, Japan.
⁵ Sports Medicine Research Center, Keio University, 4-1-1 Hiyoshi, Kohoku-ku, Yokohama, Kanagawa 223-0061, Japan; Department of Physical Therapy, Graduate School of Health Sciences, Tokyo Metropolitan University, 7-2-10 Higashi-Ogu, Arakawa-ku, Tokyo 116-8551, Japan.
⁶ Centre for Supercentenarian Medical Research, Keio University School of Medicine, 35 Shinano-machi, Shinjuku-ku, Tokyo 160-8582, Japan; Faculty of Nursing and Medical Care, Keio University, 5322 Endo, Fujisawa, Kanagawa 252-0882, Japan.
⁷ Department of Orthopedic Surgery, Keio University School of Medicine, 35 Shinano-machi, Shinjuku-ku, Tokyo 160-8582, Japan; Department of Orthopedic Surgery, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto 860-8556, Japan. Electronic address: miyamoto.takeshi@kuh.kumamoto-u.ac.jp.

PMID: 36182103
DOI: 10.1016/j.bone.2022.116570

Abstract

It is mandatory to manage musculoskeletal disorders in the elderly to prevent their becoming bed-ridden or requiring long-term care. However, the prevalence of musculoskeletal disorders such as osteoporosis and sarcopenia in otherwise healthy people over 85 years old is not completely known. Here we enrolled 1026 healthy subjects between 85 and 89 years old and evaluated them for the presence of osteoporosis, sarcopenia and fragility fracture(s), and how those conditions were related. We also evaluated biomarkers such as serum levels of insulin-like growth factor 1 (IGF1) and vitamin D status. The prevalence of osteoporosis, sarcopenia or fragility fracture(s) in these subjects was 22.4, 10.2 or 15.0 %, respectively. Serum IGF1 and 25(OH)D were significantly and negatively correlated with osteoporosis or sarcopenia. Osteoporosis and either sarcopenia or fragility fracture(s) were significantly related and shown to be risk factors for each other, even after adjustment for gender and BMI, while sarcopenia and fragility fracture(s) were not associated. Our data may provide a health platform for the very elderly and suggest strategies to prevent musculoskeletal disorders in this population.

Keywords: Fragility fracture; Osteoporosis; Sarcopenia; Very old people.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Aged
Aged, 80 and over
Bone Density
Fractures, Bone* / epidemiology
Humans
Insulin-Like Growth Factor I
Osteoporosis* / complications
Osteoporosis* / epidemiology
Sarcopenia* / complications
Sarcopenia* / epidemiology
Vitamin D

Substances

Insulin-Like Growth Factor I
Vitamin D
IGF1 protein, human