Background: Thermoreceptors include TRPV1 and TRPM8. TRPV1 and TRPM8 are TRP channels. TRP ion channels are widely expressed in many different tissues and cell types, and are involved in different physiological processes. Research on the structure and basic physiological functions of TRPV1 is relatively perfect, and the relationship between the pathogenesis of other members of the TRP family and specific diseases and TRPV1 remains to be explored in depth.
Methods: Articles regarding TRP were culled from the Web of Science Core Collection, and knowledge maps were generated using the CiteSpace software.
Results: In total, 19,862 articles were included. The number of published articles on this topic has rapidly increased since 2000, with more than 1000 articles published per year by 2020. MAKOTO TOMINAGA was the author with the most articles. The countries with the most articles were the United States and China. However, the number of articles in the U.S. was 3 times that in China. The organizations that publish the most articles are Harvard University in the US and Seoul Natl University in South Korea. TRP and the pathogenesis of diseases, such as neuropathy and stroke, are hotspots of current research.
Conclusion: To our knowledge, this is the first study to provide an overview of the literature on TRP. Research on TRPs is developing rapidly.
Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc.