Brain Injury in Infants Evaluated for, But Not Treated with, Therapeutic Hypothermia

Kirsten R Thiim; Aisling A Garvey; Elizabeth Singh; Brian Walsh; Terrie E Inder; Mohamed El-Dib

doi:10.1016/j.jpeds.2022.09.027

Brain Injury in Infants Evaluated for, But Not Treated with, Therapeutic Hypothermia

J Pediatr. 2023 Feb:253:304-309. doi: 10.1016/j.jpeds.2022.09.027. Epub 2022 Sep 27.

Authors

Kirsten R Thiim¹, Aisling A Garvey², Elizabeth Singh¹, Brian Walsh³, Terrie E Inder⁴, Mohamed El-Dib⁵

Affiliations

¹ Department of Pediatric Newborn Medicine, Brigham and Women's Hospital, Boston, MA.
² Department of Pediatric Newborn Medicine, Brigham and Women's Hospital, Boston, MA; INFANT Research Centre, University College Cork, Cork, Ireland; Department of Paediatrics and Child Health, University College Cork, Cork, Ireland; Harvard Medical School, Boston, MA.
³ Department of Pediatric Newborn Medicine, Brigham and Women's Hospital, Boston, MA; INFANT Research Centre, University College Cork, Cork, Ireland; Department of Paediatrics and Child Health, University College Cork, Cork, Ireland; Department of Neonatology, Cork University Maternity Hospital, Cork, Ireland.
⁴ Department of Pediatric Newborn Medicine, Brigham and Women's Hospital, Boston, MA; Harvard Medical School, Boston, MA.
⁵ Department of Pediatric Newborn Medicine, Brigham and Women's Hospital, Boston, MA; Harvard Medical School, Boston, MA. Electronic address: mel-dib@bwh.harvard.edu.

PMID: 36179889
DOI: 10.1016/j.jpeds.2022.09.027

Abstract

Defining neonatal encephalopathy clinically to qualify for therapeutic hypothermia is challenging. This study examines magnetic resonance imaging outcomes of 39 infants who were evaluated and not cooled using criteria inclusive of mild encephalopathy. Infants evaluated for therapeutic hypothermia are at risk for brain injury and may benefit from neuroimaging and follow-up.

Keywords: hypoxic–ischemic encephalopathy; magnetic resonance imaging; neonatal encephalopathy.

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

Brain Injuries*
Humans
Hypothermia, Induced* / methods
Hypoxia-Ischemia, Brain* / pathology
Hypoxia-Ischemia, Brain* / therapy
Infant
Infant, Newborn
Infant, Newborn, Diseases* / therapy
Magnetic Resonance Imaging / methods
Severity of Illness Index