Indole alkaloids fusarindoles A-E from marine-derived fungus Fusarium equiseti LJ-1

Xiao-Ming Dai; Hui-Lin Pan; Wen-Jian Lan; Liu-Ping Chen; Gong-Kan Feng; Rong Deng; Xiao-Feng Zhu; Hou-Jin Li

doi:10.1016/j.phytochem.2022.113456

Indole alkaloids fusarindoles A-E from marine-derived fungus Fusarium equiseti LJ-1

Phytochemistry. 2022 Dec:204:113456. doi: 10.1016/j.phytochem.2022.113456. Epub 2022 Sep 27.

Authors

Xiao-Ming Dai¹, Hui-Lin Pan², Wen-Jian Lan³, Liu-Ping Chen⁴, Gong-Kan Feng⁵, Rong Deng⁶, Xiao-Feng Zhu⁷, Hou-Jin Li⁸

Affiliations

¹ School of Chemistry, Sun Yat-sen University, Guangzhou, 510006, China. Electronic address: 952087465@qq.com.
² School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, China. Electronic address: panhlin3@mail2.sysu.edu.cn.
³ School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, China. Electronic address: lanwj@mail.sysu.edu.cn.
⁴ School of Chemistry, Sun Yat-sen University, Guangzhou, 510006, China. Electronic address: cesclp@mail.sysu.edu.cn.
⁵ State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Cancer Center, Sun Yat-sen University, Guangzhou, 510060, China. Electronic address: fenggk@sysucc.org.cn.
⁶ State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Cancer Center, Sun Yat-sen University, Guangzhou, 510060, China. Electronic address: dengrong@sysucc.org.cn.
⁷ State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Cancer Center, Sun Yat-sen University, Guangzhou, 510060, China. Electronic address: zhuxfeng@mail.sysu.edu.cn.
⁸ School of Chemistry, Sun Yat-sen University, Guangzhou, 510006, China. Electronic address: ceslhj@mail.sysu.edu.cn.

PMID: 36179822
DOI: 10.1016/j.phytochem.2022.113456

Abstract

Five undescribed indole alkaloids, fusarindoles A-E, together with seven known compounds were obtained from the marine-derived fungus Fusarium equiseti LJ-1. Their chemical structures and absolute configurations were determined by comprehensive analysis of the NMR, HRMS, UV, IR, ECD calculation and single-crystal X-ray diffraction data. The possible biosynthetic pathways of fusarindoles C-E were proposed. The cytotoxicities of eleven compounds, including fusarindoles A-E and six known compounds, against five human cancer cell lines A549, CNE2, SUNE1, HepG2 and QGY7701 were evaluated.

Keywords: Cytotoxic activity; Fusarindole; Fusarium equiseti; Marine fungus; Nectriaceae.