Unpacking circulating tumor DNA lends insight into prostate cancer biology and the clonal dynamics of metastasis

David Y Takeda; Adam G Sowalsky

doi:10.1016/j.ccell.2022.09.002

Unpacking circulating tumor DNA lends insight into prostate cancer biology and the clonal dynamics of metastasis

Cancer Cell. 2022 Oct 10;40(10):1086-1088. doi: 10.1016/j.ccell.2022.09.002. Epub 2022 Sep 29.

Authors

David Y Takeda¹, Adam G Sowalsky²

Affiliations

¹ Laboratory of Genitourinary Cancer Pathogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 37 Convent Drive, Bethesda, MD 20892, USA.
² Laboratory of Genitourinary Cancer Pathogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 37 Convent Drive, Bethesda, MD 20892, USA. Electronic address: adam.sowalsky@nih.gov.

PMID: 36179684
DOI: 10.1016/j.ccell.2022.09.002

Abstract

Prostate cancer (PCa) frequently metastasizes to bone, and analyses of DNA from bone biopsies are exceptionally challenging. A recent report in Nature demonstrates that whole-genome sequencing (WGS) of circulating tumor DNA (ctDNA) from patients with metastatic PCa can inform on the subclonal composition of metastatic disease and infer patterns of gene expression.

Published by Elsevier Inc.

MeSH terms

Biology
Biomarkers, Tumor / genetics
Circulating Tumor DNA* / genetics
Humans
Male
Mutation
Neoplasm Metastasis
Prostatic Neoplasms* / genetics
Prostatic Neoplasms* / pathology
Whole Genome Sequencing

Substances

Biomarkers, Tumor
Circulating Tumor DNA