The role of lncRNA just proximal to XIST (JPX) in human disease phenotypes and RNA methylation: The novel biomarker and therapeutic target potential

Yirui Kuang; Wenyue Shen; Hecheng Zhu; Haoxuan Huang; Quanwei Zhou; Wen Yin; Yi Zhou; Yudong Cao; Lei Wang; Xuewen Li; Caiping Ren; Xingjun Jiang

doi:10.1016/j.biopha.2022.113753

The role of lncRNA just proximal to XIST (JPX) in human disease phenotypes and RNA methylation: The novel biomarker and therapeutic target potential

Biomed Pharmacother. 2022 Nov:155:113753. doi: 10.1016/j.biopha.2022.113753. Epub 2022 Sep 28.

Authors

Yirui Kuang¹, Wenyue Shen¹, Hecheng Zhu², Haoxuan Huang¹, Quanwei Zhou¹, Wen Yin¹, Yi Zhou¹, Yudong Cao¹, Lei Wang³, Xuewen Li², Caiping Ren⁴, Xingjun Jiang⁵

Affiliations

¹ Department of Neurosurgery, National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan Province 410008, China; Cancer Research Institute, School of Basic Medical Science, Central South University, Changsha, Hunan Province 410008, China.
² Changsha Kexin Cancer Hospital, Changsha, Hunan Province 410205, China.
³ Cancer Research Institute, School of Basic Medical Science, Central South University, Changsha, Hunan Province 410008, China; The NHC Key Laboratory of Carcinogenesis and The Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Central South University, Changsha, Hunan Province 410078, China.
⁴ Department of Neurosurgery, National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan Province 410008, China; Cancer Research Institute, School of Basic Medical Science, Central South University, Changsha, Hunan Province 410008, China; The NHC Key Laboratory of Carcinogenesis and The Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Central South University, Changsha, Hunan Province 410078, China. Electronic address: rencaiping@csu.edu.cn.
⁵ Department of Neurosurgery, National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan Province 410008, China. Electronic address: jiangxj@csu.edu.cn.

PMID: 36179492
DOI: 10.1016/j.biopha.2022.113753

Abstract

Increasing evidence suggests that long non-coding RNAs (lncRNAs) are closely related to the initialization and development of human diseases. lncRNA just proximal to XIST (JPX), as a newly identified lncRNA, has been reported to be aberrantly expressed and associated with pathophysiological traits in numerous diseases, particularly cancers. More importantly, JPX has been proven to play important roles in various biological functions, including cell proliferation, migration, invasion, apoptosis, chemoresistance, and differentiation. In addition, we discuss the diverse molecular mechanisms and correlation with RNA methylation of JPX in several cancers. In this Review, we summarize current studies on JPX's roles in diseases and its potential application as a biomarker for both diagnoses and prognoses and a therapeutic target in human diseases.

Keywords: Biomarker; Function; JPX; LncRNA; Mechanisms; TCGA.

Publication types

Review

MeSH terms

Biomarkers
Humans
Methylation
Neoplasms* / diagnosis
Neoplasms* / drug therapy
Neoplasms* / genetics
Phenotype
RNA, Long Noncoding* / genetics
RNA, Long Noncoding* / metabolism

Substances

Biomarkers
RNA, Long Noncoding
XIST non-coding RNA