We address the formation of topological states in twisted circular waveguide arrays and find that twisting leads to important differences of the fundamental properties of new vortex solitons with opposite topological charges that arise in the nonlinear regime. We find that such system features the rare property that clockwise and counterclockwise vortex states are nonequivalent. Focusing on arrays with C_{6v} discrete rotation symmetry, we find that a longitudinal twist stabilizes the vortex solitons with the lowest topological charges m=±1, which are always unstable in untwisted arrays with the same symmetry. Twisting also leads to the appearance of instability domains for otherwise stable solitons with m=±2 and generates vortex modes with topological charges m=±3 that are forbidden in untwisted arrays. By and large, we establish a rigorous relation between the discrete rotation symmetry of the array, its twist direction, and the possible soliton topological charges.