Molecular diagnosis and treatment of meningiomas: an expert consensus (2022)

Jiaojiao Deng; Lingyang Hua; Liuguan Bian; Hong Chen; Ligang Chen; Hongwei Cheng; Changwu Dou; Dangmurenjiapu Geng; Tao Hong; Hongming Ji; Yugang Jiang; Qing Lan; Gang Li; Zhixiong Liu; Songtao Qi; Yan Qu; Songsheng Shi; Xiaochuan Sun; Haijun Wang; Yongping You; Hualin Yu; Shuyuan Yue; Jianming Zhang; Xiaohua Zhang; Shuo Wang; Ying Mao; Ping Zhong; Ye Gong; Group of Neuro-Oncology, Society of Neurosurgery, Chinese Medical Association

doi:10.1097/CM9.0000000000002391

Molecular diagnosis and treatment of meningiomas: an expert consensus (2022)

Chin Med J (Engl). 2022 Aug 20;135(16):1894-1912. doi: 10.1097/CM9.0000000000002391.

Authors

Jiaojiao Deng^{1

2}, Lingyang Hua^{3

4

5}, Liuguan Bian⁶, Hong Chen⁷, Ligang Chen⁸, Hongwei Cheng⁹, Changwu Dou¹⁰, Dangmurenjiapu Geng¹¹, Tao Hong¹², Hongming Ji¹³, Yugang Jiang¹⁴, Qing Lan¹⁵, Gang Li¹⁶, Zhixiong Liu¹⁷, Songtao Qi¹⁸, Yan Qu¹⁹, Songsheng Shi²⁰, Xiaochuan Sun²¹, Haijun Wang²², Yongping You²³, Hualin Yu²⁴, Shuyuan Yue²⁵, Jianming Zhang²⁶, Xiaohua Zhang²⁷, Shuo Wang²⁸, Ying Mao¹, Ping Zhong^{3

4

5}, Ye Gong^{1

2}; Group of Neuro-Oncology, Society of Neurosurgery, Chinese Medical Association

Affiliations

¹ Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai 200040, China.
² National Center for Neurological Disorders, Huashan Hospital, Fudan University, Shanghai 200040, China.
³ Shanghai Key Laboratory of Brain Function and Restoration and Neural Regeneration, Shanghai 200040, China.
⁴ Neurosurgical Institute of Fudan University, Shanghai 200040, China.
⁵ Shanghai Clinical Medical Center of Neurosurgery, Shanghai 200040, China.
⁶ Department of Neurosurgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
⁷ Department of Pathology, Huashan Hospital, Fudan University, Shanghai 200040, China.
⁸ Department of Neurosurgery, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, China.
⁹ Department of Neurosurgery, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, China.
¹⁰ Department of Neurosurgery, The Affiliated Hospital of Inner Mongolia Medical University, Hohhot, Inner Mongolia 750306, China.
¹¹ Department of Neurosurgery, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang 830011, China.
¹² Department of Neurosurgery, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, China.
¹³ Department of Neurosurgery, Shanxi Medical University Shanxi Provincial People's Hospital, Taiyuan, Shanxi 030012, China.
¹⁴ Department of Neurosurgery, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China.
¹⁵ Department of Neurosurgery, The Second Affiliated Hospital of Soochow University, Soochow, Jiangsu 215004, China.
¹⁶ Department of Neurosurgery, Qilu Hospital, Cheeloo College of Medicine and Institute of Brain and Brain-Inspired Science, Shandong University, Jinan, Shandong 250063, China.
¹⁷ Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China.
¹⁸ Department of Neurosurgery, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, China.
¹⁹ Department of Neurosurgery, Tangdu Hospital, The Fourth Military Medical University, Xi'an, Shaanxi 710038, China.
²⁰ Department of Neurosurgery, Fujian Medical University Affiliated Union Hospital, Fuzhou, Fujian 350001, China.
²¹ Department of Neurosurgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400042, China.
²² Department of Neurosurgery, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong 510080, China.
²³ Department of Neurosurgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, China.
²⁴ Department of Neurosurgery, Kunming Medical University First Affiliated Hospital, Kunming, Yunnan 650032, China.
²⁵ Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin 300052, China.
²⁶ Department of Neurosurgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310003, China.
²⁷ Department of Neurosurgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China.
²⁸ Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China.

Abstract

Abstract: Meningiomas are the most common primary intracranial neoplasm with diverse pathological types and complicated clinical manifestations. The fifth edition of the WHO Classification of Tumors of the Central Nervous System (WHO CNS5), published in 2021, introduces major changes that advance the role of molecular diagnostics in meningiomas. To follow the revision of WHO CNS5, this expert consensus statement was formed jointly by the Group of Neuro-Oncology, Society of Neurosurgery, Chinese Medical Association together with neuropathologists and evidence-based experts. The consensus provides reference points to integrate key biomarkers into stratification and clinical decision making for meningioma patients.

Registration: Practice guideline REgistration for transPAREncy (PREPARE), IPGRP-2022CN234.

MeSH terms

Consensus
Humans
Meningeal Neoplasms* / diagnosis
Meningeal Neoplasms* / pathology
Meningioma* / diagnosis
Meningioma* / pathology
Neurosurgical Procedures