Protein-Metabolite Interactions Shape Cellular Metabolism and Physiology

Prathibha Muralidhara; Jennifer C Ewald

doi:10.1007/978-1-0716-2624-5_1

Protein-Metabolite Interactions Shape Cellular Metabolism and Physiology

Methods Mol Biol. 2023:2554:1-10. doi: 10.1007/978-1-0716-2624-5_1.

Authors

Prathibha Muralidhara¹, Jennifer C Ewald²

Affiliations

¹ Interfaculty Institute of Cell Biology, University of Tübingen, Tübingen, Germany. prathibha.muralidhara@uni-tuebingen.de.
² Interfaculty Institute of Cell Biology, University of Tübingen, Tübingen, Germany.

PMID: 36178616
DOI: 10.1007/978-1-0716-2624-5_1

Abstract

Protein-metabolite interactions regulate many important cellular processes but still remain understudied. Recent technological advancements are gradually uncovering the complexity of the protein-metabolite interactome. Here, we highlight some classic and recent examples of how protein metabolite interactions regulate metabolism, both locally and globally, and how this contributes to cellular physiology. We also discuss the importance of these interactions in diseases such as cancer.

Keywords: Allosteric regulation; Interactome; Metabolic disease; Metabolic regulation; Metabolism; PMI; Protein–metabolite interactions; Signaling; Small molecule regulators.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Proteins* / metabolism

Substances

Proteins