Beyond 1,2,3-Triazoles: Formation and Applications of Ketenimines Derived from Copper Catalyzed Azide Alkyne Cycloaddition

Flor María Escandón-Mancilla; Nelly González-Rivas; M V Basavanag Unnamatla; Marco A García-Eleno; David Corona-Becerril; Bernardo A Frontana-Uribe; Erick Cuevas-Yañez

doi:10.2174/1570179420666220929152449

Beyond 1,2,3-Triazoles: Formation and Applications of Ketenimines Derived from Copper Catalyzed Azide Alkyne Cycloaddition

Curr Org Synth. 2022 Sep 29. doi: 10.2174/1570179420666220929152449. Online ahead of print.

Authors

Affiliations

¹ Centro Conjunto de Investigación en Química Sustentable UAEM-UNAM, Carretera Toluca-Atlacomulco Km. 14.5, Toluca, Estado de México 50200, Mexico.
² Facultad de Química, Universidad Autónoma del Estado de México. Paseo Colón esq. Paseo Tollocan, 50120, Toluca, Mexico.
³ Instituto de Química, Universidad Nacional Autónoma de México, Circuito Exterior, Ciudad Universitaria, Ciudad de México 04510, Mexico.

PMID: 36177624
DOI: 10.2174/1570179420666220929152449

Abstract

The ketenimines represent an interesting class of organic intermediates which has undergone a regrowth as a consequence of recent extensions of copper catalyzed azide alkyne cycloaddition (CuAAC) to other synthetic fields. This review summarizes the most recent generation methods of ketinimines from CuAAC reaction, highlighting chemical properties focused to the synthesis of cyclic compounds among others, affording a general outlook towards the development of new biologically active compounds.

Keywords: Ketenimine; alkyne; azide; copper catalyzed azide alkyne cycloaddition..