DNA damage response and GATA4 signaling in cellular senescence and aging-related pathology

Hao Xiong; Fuzhou Hua; Yao Dong; Yue Lin; Jun Ying; Jie Liu; Xifeng Wang; Lieliang Zhang; Jing Zhang

doi:10.3389/fnagi.2022.933015

DNA damage response and GATA4 signaling in cellular senescence and aging-related pathology

Front Aging Neurosci. 2022 Sep 13:14:933015. doi: 10.3389/fnagi.2022.933015. eCollection 2022.

Authors

Hao Xiong^{1

2}, Fuzhou Hua^{1

2}, Yao Dong³, Yue Lin^{1

2}, Jun Ying^{1

2}, Jie Liu^{1

2}, Xifeng Wang³, Lieliang Zhang^{1

2}, Jing Zhang¹

Affiliations

¹ Department of Anesthesiology, The Second Affiliated Hospital of Nanchang University, Nanchang, China.
² Key Laboratory of Anesthesiology of Jiangxi Province, Nanchang, China.
³ Department of Anesthesiology, The First Affiliated Hospital of Nanchang University, Nanchang, China.

Abstract

Aging is the continuous degradation of biological function and structure with time, and cellular senescence lies at its core. DNA damage response (DDR) can activate Ataxia telangiectasia-mutated serine/threonine kinase (ATM) and Rad3-related serine/threonine kinase (ATR), after which p53 activates p21, stopping the cell cycle and inducing cell senescence. GATA4 is a transcription factor that plays an important role in the development of many organs, such as the heart, testis, ovary, foregut, liver, and ventral pancreas. Studies have shown that GATA4 can also contribute to the DDR, leading to aging. Consistently, there is also evidence that the GATA4 signaling pathway is associated with aging-related diseases, including atherosclerosis and heart failure. This paper reviews the relationship between GATA4, DDR, and cellular senescence, as well as its effect on aging-related diseases.

Keywords: CGATA4; DNA damage response; atherosclerosis; cellular senescence; heart failure.

Publication types

Review