Influence of Subclinical Hypothyroidism on Women With Polycystic Ovary Syndrome: A Literature Review

Aishwarya Peddemul; Sreedevi Tejovath; Danial Hassan; Khushbu K Patel; Rabia Sikandar; Simranjit S Kahlon; Shaalina Nair; Jihan A Mostafa

doi:10.7759/cureus.28468

Influence of Subclinical Hypothyroidism on Women With Polycystic Ovary Syndrome: A Literature Review

Cureus. 2022 Aug 27;14(8):e28468. doi: 10.7759/cureus.28468. eCollection 2022 Aug.

Authors

Aishwarya Peddemul¹, Sreedevi Tejovath², Danial Hassan^{3

4}, Khushbu K Patel², Rabia Sikandar², Simranjit S Kahlon², Shaalina Nair², Jihan A Mostafa²

Affiliations

¹ Obstetrics and Gynecology, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA.
² Internal Medicine, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA.
³ Department of Health Care Profession, Ministry of Public Health, Doha, QAT.
⁴ Cardiology, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA.

Abstract

Subclinical hypothyroidism (SCH) is a commonly encountered condition in women with polycystic ovary syndrome (PCOS). Nevertheless, it is unclear whether SCH has any potential impact on the metabolic and reproductive profiles of women with PCOS. Hence, this literature review explores and establishes the link between these two conditions. In women with PCOS, SCH was found to aggravate insulin resistance and dyslipidemia. It was also linked to hormonal imbalances leading to higher infertility rates among the PCOS-SCH group. Therefore, women with PCOS must be screened for thyroid function frequently and managed accordingly.

Keywords: dyslipidemia; female infertility; homeostatic model assessment of insulin resistance (homa-ir); polycystic ovary syndrome (pcos); subclinical hypothyroidism.

Publication types

Review