Hypofibrinogenemia and miscarriage: report of a first successful pregnancy under fibrinogen substitution and short review of the literature

Christoph Sucker; Christof Geisen; Ursula Schmitt; Bartosz Zawislak

doi:10.22551/2022.36.0903.10211

Hypofibrinogenemia and miscarriage: report of a first successful pregnancy under fibrinogen substitution and short review of the literature

Arch Clin Cases. 2022 Sep 26;9(3):100-103. doi: 10.22551/2022.36.0903.10211. eCollection 2022.

Authors

Christoph Sucker^{1

2}, Christof Geisen³, Ursula Schmitt¹, Bartosz Zawislak¹

Affiliations

¹ Coagumed Coagulation Center, Berlin, Germany.
² Medical School Brandenburg, Brandenburg an der Havel, Germany.
³ Institute of Transfusion Medicine and Immunohaematology, German Red Cross Blood Transfusion Service Baden-Württemberg-Hessen gGmbH, Goethe University Hospital Frankfurt/Main, Frankfurt am Main, Germany.

Abstract

Disorders of fibrinogen have been reported to be associated not only with bleeding and thrombosis but also with miscarriage. Here, we report the case of a woman with genetically determined hypofibrinogenemia and recurrent miscarriages who had a first successful pregnancy under fibrinogen substitution. Current knowledge on fibrinogen disorders and recurrent miscarriages is briefly summarized and discussed.

Keywords: fibrinogen substitution; hypofibrinogenemia; miscarriage.

Publication types

Case Reports