After a stroke, the weight-bearing asymmetry often forces stroke survivors to compensate with overuse of the unaffected side muscles to stand up. Powered exoskeletons can address this problem by assisting the affected limb during sit-tostand transitions. However, there is currently no experimental evidence demonstrating the efficacy of this intervention with the target population. This study explores controlling a powered knee exoskeleton with EMG signals to assist a stroke patient during sit-to-stand transitions. Our results show decreased peak knee torques by 6.24% and 11.9% on their unaffected and affected sides, respectively, while wearing the exoskeleton. Additionally, the peak value of the EMG signal decreased by 29.3% and 21.9%, and the integrated EMG signal value decreased by 46.7% and 36.1% on their affected vastus medialis and lateralis while wearing the exoskeleton, respectively. Finally, our results indicate improved medial-lateral balance by 61.2%, 81.6%, and 70.0% based on the degree of asymmetry (DOA), the center of pressure (COP), and the center of mass (COM), respectively. These results support the efficacy of using powered exoskeletons for high-torque tasks such as sit-to-stand transitions with stroke survivors.