Exposure to particulate matter ≤2.5 μm in diameter (PM2.5) alters cardiometabolic homeostasis. The reduced oxidative capacity in brown adipocytes and the development of inflammation and insulin resistance in white adipose tissue (WAT) can account for the dysmetabolic setting on PM2.5 exposure. In this forum article, we discuss relevant evidence to highlight a causal connection between PM2.5-induced adipose tissue dysfunction and cardiometabolic disturbances.
Keywords: adipocytes; air pollution; cardiovascular; inflammation; insulin resistance; particulate matter.
Copyright © 2022 Elsevier Ltd. All rights reserved.