Transplantation of Nasal Olfactory Mucosa Mesenchymal Stem Cells Benefits Alzheimer's Disease

Chun-Gu Hong; Meng-Lu Chen; Ran Duan; Xin Wang; Zhi-Lin Pang; Li-Te Ge; Ming Lu; Hui Xie; Zheng-Zhao Liu

doi:10.1007/s12035-022-03044-6

Transplantation of Nasal Olfactory Mucosa Mesenchymal Stem Cells Benefits Alzheimer's Disease

Mol Neurobiol. 2022 Dec;59(12):7323-7336. doi: 10.1007/s12035-022-03044-6. Epub 2022 Sep 29.

Authors

Chun-Gu Hong^#^{1

2}, Meng-Lu Chen^#³, Ran Duan^#³, Xin Wang³, Zhi-Lin Pang³, Li-Te Ge^{4

5}, Ming Lu^#⁶, Hui Xie^#^{7

8

9}, Zheng-Zhao Liu^#^{10

11

12}

Affiliations

¹ Department of Orthopedics, Movement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China.
² National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China.
³ Department of Sports Medicine, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China.
⁴ Department of Neurosurgery, Second Affiliated Hospital of Hunan Normal University (921 Hospital of PLA), Changsha, 410081, Hunan, China.
⁵ Department of Neurology, Second Xiangya Hospital, Central South University, Changsha, 410011, Hunan, China.
⁶ Department of Neurosurgery, Second Affiliated Hospital of Hunan Normal University (921 Hospital of PLA), Changsha, 410081, Hunan, China. lumingcs163@126.com.
⁷ Department of Orthopedics, Movement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China. huixie@csu.edu.cn.
⁸ National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China. huixie@csu.edu.cn.
⁹ Department of Sports Medicine, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China. huixie@csu.edu.cn.
¹⁰ Department of Orthopedics, Movement System Injury and Repair Research Center, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China. liuzhengzhao@csu.edu.cn.
¹¹ National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China. liuzhengzhao@csu.edu.cn.
¹² Department of Sports Medicine, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China. liuzhengzhao@csu.edu.cn.

^# Contributed equally.

PMID: 36173534
DOI: 10.1007/s12035-022-03044-6

Abstract

Alzheimer's disease (AD) is a common neurodegenerative disease that contributes to 60-70% of dementia in elderly people and is currently incurable. Current treatments only relieve the symptoms of AD and slow its progression. Achieving effective neural regeneration to ameliorate cognitive impairment is a major challenge in the treatment of AD. For the first time, we alleviated symptoms of AD in APPswe/PS1dE9 mice (hereafter referred to as AD mice) by transplantation of olfactory mucosa mesenchymal stem cells (OM-MSCs). Our study demonstrated that OM-MSC transplantation promotes amyloid-β (Aβ) clearance, downregulates the inflammatory response, and increases the M2/M1 ratio; OM-MSCs promote the conversion of BV2 (microglia) from M1 to M2 and also Aβ clearance in SH-SY5Y^APPswe (AD cell model). OM-MSC-transplanted AD mice show improved cognitive learning and locomotive behavior. Our study suggests that OM-MSC transplantation could alleviate the symptoms of AD and promote Aβ clearance through immunomodulation, thus demonstrating the great potential and social value of OM-MSC treatment for AD patients.

Keywords: Alzheimer’s disease; Mesenchymal stem cells; Olfactory mucosa mesenchymal stem cells; Transplantation.

MeSH terms

Alzheimer Disease* / therapy
Amyloid beta-Peptides
Animals
Disease Models, Animal
Humans
Mesenchymal Stem Cell Transplantation*
Mesenchymal Stem Cells*
Mice
Mice, Transgenic
Neuroblastoma*
Neurodegenerative Diseases*
Olfactory Mucosa

Substances

Amyloid beta-Peptides

Abstract

MeSH terms

Substances

Grants and funding