Contribution of ZBTB20 Polymorphisms to Esophageal Cancer Risk Among the Chinese Han Population

Shuyong Yu; Guihong Yuan; Feixiang Hu; Yongyu Li; Zhuang Chen; Ronglin Zhang; Ping Li; Zhaowei Chen; Jian Song

doi:10.2147/PGPM.S370963

Contribution of ZBTB20 Polymorphisms to Esophageal Cancer Risk Among the Chinese Han Population

Pharmgenomics Pers Med. 2022 Sep 20:15:827-842. doi: 10.2147/PGPM.S370963. eCollection 2022.

Authors

Shuyong Yu^#¹, Guihong Yuan^#², Feixiang Hu^#¹, Yongyu Li², Zhuang Chen², Ronglin Zhang³, Ping Li³, Zhaowei Chen², Jian Song⁴

Affiliations

¹ Department of Gastrointestinal Surgery, Hainan Cancer Hospital, Haikou, 570100, People's Republic of China.
² Department of Gastroenterology, Hainan Cancer Hospital, Haikou, 570100, People's Republic of China.
³ Digestive Endoscopy Center, Hainan Cancer Hospital, Haikou, 570100, People's Republic of China.
⁴ Department of Gastroenterology, Southern University of Science and Technology Hospital, Shenzhen, 518000, People's Republic of China.

^# Contributed equally.

Abstract

Background: ZBTB20 was overexpressed in esophageal cancer (EC). The study aimed to identify genotypes of ZBTB20 polymorphisms and their correlation with EC occurrence in a Chinese Han population.

Methods: Four single nucleotide polymorphisms (SNPs) in ZBTB20 were randomly selected for genotyping through Agena MassARRAY system among 525 EC patients and 522 healthy controls. Multiple genetic models were applied to assess the association of ZBTB20 polymorphisms with EC susceptibility by calculating odds ratios (ORs) with 95% confidence intervals (CIs).

Results: Rs10934270 was associated with lower EC susceptibility (OR = 0.64, p = 0.004) with statistical power >90% in overall analysis. Specifically, the correlation of rs10934270 with EC susceptibility was found in subgroups including patients with esophageal squamous cell carcinoma (ESCC), males, subjects aged ≤65 years, subjects with BMI ≤ 24 kg/m², and smokers. Rs9841504 might be a risk-increasing factor for ESCC. Moreover, rs9288999 in subjects aged ≤65 years and rs73230612 in females were related to lower EC risk.

Conclusion: Our research is the first to report that ZBTB20 rs10934270 is associated with reduced EC susceptibility in the Chinese Han population. These data provide a scientific basis for understanding the influence of the ZBTB20 gene on EC occurrence.

Keywords: FPRP analysis; ZBTB20; esophageal cancer; genetic polymorphisms; genotype–phenotype analyses.

Grants and funding

This work was supported by 2020 Hainan Province Major Science and Technology Plan Project (ZDKJ202005) and Supported by the specific research fund of The Innovation Platform for Academinicians of Hainan Province.