Dual drug delivery platforms for bone tissue engineering

Anupama Devi V K; Sarbajit Ray; Udita Arora; Sunrito Mitra; Alina Sionkowska; Amit Kumar Jaiswal

doi:10.3389/fbioe.2022.969843

Dual drug delivery platforms for bone tissue engineering

Front Bioeng Biotechnol. 2022 Sep 12:10:969843. doi: 10.3389/fbioe.2022.969843. eCollection 2022.

Authors

Anupama Devi V K^{1

2}, Sarbajit Ray², Udita Arora², Sunrito Mitra², Alina Sionkowska³, Amit Kumar Jaiswal¹

Affiliations

¹ Tissue Engineering Group, Centre for Biomaterials, Cellular and Molecular Theranostics (CBCMT), Vellore Institute of Technology (VIT), Vellore, India.
² School of Bio Sciences and Technology (SBST), Vellore Institute of Technology (VIT), Vellore, India.
³ Nicolaus Copernicus University, Torun, Poland.

Abstract

The dual delivery platforms used in bone tissue engineering provide supplementary bioactive compounds that include distinct medicines and growth factors thereby aiding enhanced bone regeneration. The delivery of these compounds can be adjusted for a short or prolonged time based on the requirement by altering various parameters of the carrier platform. The platforms thus used are fabricated to mimic the niche of the bone microenvironment, either in the form of porous 3D structures, microspheres, or films. Thus, this review article focuses on the concept of dual drug delivery platform and its importance, classification of various platforms for dual drug delivery specific to bone tissue engineering, and finally highlights the foresight into the future direction of these techniques for better clinical applications.

Keywords: bone regeneration; bone tissue engineering; dual drug delivery platform; growth factors; osteogenesis; scaffolds.

Publication types

Review