Artificial intelligence (AI) in cardiology represents a great opportunity, if further developed in a trustworthy way, to support human intelligence in daily practice. AI could help cardiologists to operate with greater efficacy and efficiency, supporting precision, timeliness, ethics, while meeting all patients' needs. AI, however, is not yet so widely diffused in cardiology and important challenges and obstacles have to be overcome, concerning ethics, conflict of interests, algorithm improvements and transparency, product certification, input processing, cyber security, privacy, and need for collaboration and cooperation of different involved professions, within and between different institutions of heterogeneous complexity.