Annexins as potential targets in ocular diseases

Rafael André da Silva; Vinicius Moraes de Paiva Roda; Luiz Philipe de Souza Ferreira; Sonia M Oliani; Ana Paula Girol; Cristiane D Gil

doi:10.1016/j.drudis.2022.103367

Annexins as potential targets in ocular diseases

Drug Discov Today. 2022 Nov;27(11):103367. doi: 10.1016/j.drudis.2022.103367. Epub 2022 Sep 20.

Authors

Rafael André da Silva¹, Vinicius Moraes de Paiva Roda², Luiz Philipe de Souza Ferreira³, Sonia M Oliani⁴, Ana Paula Girol⁵, Cristiane D Gil⁶

Affiliations

¹ Biosciences Graduate Program, Institute of Biosciences, Letters and Exact Sciences, Universidade Estadual Paulista (UNESP), São José do Rio Preto, SP 15054-000, Brazil.
² Life Systems Biology Graduate Program, Institute of Biomedical Sciences, Universidade de São Paulo (USP), São Paulo, SP 05508-000, Brazil.
³ Structural and Functional Biology Graduate Program, Universidade Federal de São Paulo (UNIFESP), São Paulo, SP 04023-900, Brazil.
⁴ Biosciences Graduate Program, Institute of Biosciences, Letters and Exact Sciences, Universidade Estadual Paulista (UNESP), São José do Rio Preto, SP 15054-000, Brazil; Structural and Functional Biology Graduate Program, Universidade Federal de São Paulo (UNIFESP), São Paulo, SP 04023-900, Brazil; Advanced Research Center in Medicine (CEPAM) Unilago, São José do Rio Preto, SP 15030-070, Brazil.
⁵ Biosciences Graduate Program, Institute of Biosciences, Letters and Exact Sciences, Universidade Estadual Paulista (UNESP), São José do Rio Preto, SP 15054-000, Brazil; Structural and Functional Biology Graduate Program, Universidade Federal de São Paulo (UNIFESP), São Paulo, SP 04023-900, Brazil; Centro Universitário Padre Albino (UNIFIPA), Catanduva, SP 15809-144, Brazil.
⁶ Biosciences Graduate Program, Institute of Biosciences, Letters and Exact Sciences, Universidade Estadual Paulista (UNESP), São José do Rio Preto, SP 15054-000, Brazil; Structural and Functional Biology Graduate Program, Universidade Federal de São Paulo (UNIFESP), São Paulo, SP 04023-900, Brazil. Electronic address: cristiane.gil@unifesp.br.

PMID: 36165812
DOI: 10.1016/j.drudis.2022.103367

Abstract

Annexins (AnxAs) are Ca²⁺/phospholipid-binding proteins extensively studied and generally involved in several diseases. Although evidence exists regarding the distribuition of AnxAs in the visual system, their exact roles and the exact cell types of the eye where these proteins are expressed are not well-understood. AnxAs have pro-resolving roles in infectious, autoimmune, degenerative, fibrotic and angiogenic conditions, making them an important target in ocular tissue homeostasis. This review summarizes the current knowledge on the distribution and function of AnxA1-8 isoforms under normal and pathological conditions in the visual system, as well as perspectives for ophthalmologic treatments, including the potential use of the AnxA1 recombinant and/or its mimetic peptide Ac_2-26.

Keywords: Angiogenesis; Annexins; Eye; Inflammation; Retina; Therapeutic target.

Publication types

Review