The effect of platelet-rich concentrates on orthodontic tooth movement: A review of randomized controlled trials

Ke Yao; Yongzhi Wu; Jingyi Cai; Yigan Wang; Yu Shen; Dian Jing; Zhihe Zhao

doi:10.1016/j.heliyon.2022.e10604

The effect of platelet-rich concentrates on orthodontic tooth movement: A review of randomized controlled trials

Heliyon. 2022 Sep 17;8(9):e10604. doi: 10.1016/j.heliyon.2022.e10604. eCollection 2022 Sep.

Authors

Ke Yao¹, Yongzhi Wu¹, Jingyi Cai¹, Yigan Wang¹, Yu Shen², Dian Jing³, Zhihe Zhao¹

Affiliations

¹ State Key Laboratory of Oral Diseases, National Clinical Research Center of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
² School of Basic Medical Sciences, Chengdu University, Chengdu, China.
³ Department of Orthodontics, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, College of Stomatology, Shanghai Jiao Tong University, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai, China.

Abstract

Objectives: Platelet-rich concentrates, namely platelet-rich plasma (PRP) and platelet-rich fibrin (PRF), have recently shown potential roles in accelerating orthodontic tooth movement (OTM) and reducing treatment duration. Our study aims to systematically evaluate the effect of platelet-rich concentrates on OTM.

Materials and methods: An electronic search of 11 databases, followed by a hand search of reference lists of eligible studies and related reviews, was conducted up to January 2022. Randomized controlled trials investigating OTM of patients with platelet-rich concentrates were included. Risk of bias was assessed by version 2 of Cochrane tool (RoB 2) for assessing risk of bias in randomized trials.

Results: Among 715 records initially identified, 9 studies were included, of which 3 used PRP and the other 6 applied PRF. 7 studies supported a positive relationship between platelet-rich concentrates and OTM, but the other 2 studies reported a null and a negative effect of PRF, respectively. The overall qualities of evidence were moderate to high.

Conclusions: Platelet-rich concentrates as PRP and PRF seem to be effective in accelerating OTM at early stages, while their long-term efficacy remains controversial. Repeated application of platelet concentrates may increase the accelerated stability of OTM.

Keywords: Orthodontic treatment; Platelet-rich fibrin; Platelet-rich plasma; Tooth movement.