GDF15 : A modulator of immunity and a predictive biomarker of cardiovascular events : A strategy in COVID-19

Ann Cardiol Angeiol (Paris). 2023 Feb;72(1):41-43. doi: 10.1016/j.ancard.2022.09.001. Epub 2022 Sep 16.

Abstract

In the recently published manuscript entitled "GDF15 a rising modulator of immunity and a strategy in Coronavirus disease 2019 (COVID-19) in relationship with iron metabolism" and we examined the potential properties of Growth and differentiation factor 15 (GDF15) as an emerging modulator of immunity in COVID-19. We commented new aspects of the biology of GDF15 and investigated the potential value of GDF15 as a biomarker. Is GDF15 a biomarker of the inflammatory process and oxidative stress state? Recently, it was reported that 1500 clinical trials related to COVID-19 have been registered, but none have yet found an optimal strategy. In these conditions, more clinical studies are needed before any of these agents can be considered antiviral agents.

Nous avons récemment publié une revue intitulée : « GDF15 a rising modulator of immunity and a strategy in Coronavirus disease 2019 (COVID-19) in relationship with iron metabolism » et nous avons examiné les propriétés potentielles du facteur Growth and differentiation factor 15 (GDF15) comme modulateur émergeant de l'immunité dans le COVID-19. Nous nous sommes intéressés aux aspects biologiques du GDF15 comme biomarqueur. Est-ce que le GDF15 est un biomarqueur du processus inflammatoire et de l’état du stress oxydatif ? Récemment, il a été rapporté plus de 1500 projets d’études cliniques ciblés sur le COVID-19 ; mais aucune des stratégies ne semble optimale. Dans ces conditions, des études cliniques complémentaires sont nécessaires afin que les composés testés soient définis comme des agents antiviraux.

Keywords: Biomarker; COVID-19; Cardiovascular; GDF15; Immunity; biomarqueur; cardiovasculaire; immunité.

MeSH terms

  • Biomarkers
  • COVID-19*
  • Cardiovascular Diseases*
  • Growth Differentiation Factor 15
  • Humans

Substances

  • Biomarkers
  • Growth Differentiation Factor 15
  • GDF15 protein, human