GSTA4 Governs Melanoma Immune Resistance and Metastasis

Sisca Ucche; Satoru Yokoyama; Marija Mojic; Kohei Oki; Chikako Ohshima; Haruka Tsuihiji; Ichiro Takasaki; Hideaki Tahara; Yoshihiro Hayakawa

doi:10.1158/1541-7786.MCR-22-0369

GSTA4 Governs Melanoma Immune Resistance and Metastasis

Mol Cancer Res. 2023 Jan 3;21(1):76-85. doi: 10.1158/1541-7786.MCR-22-0369.

Authors

Affiliations

¹ Institute of Natural Medicine, University of Toyama, Toyama, Japan.
² Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan.
³ Department of Pharmacology, Graduate School of Science and Engineering, Graduate School of Innovative Life Sciences, University of Toyama, Toyama, Japan.
⁴ The, Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
⁵ Department of Cancer Drug Discovery and Development, Research Center, Osaka International Cancer Institute, Osaka, Japan.

PMID: 36162957
DOI: 10.1158/1541-7786.MCR-22-0369

Abstract

Considering the importance of GSTA4 in controlling IFNγ responsiveness and the metastatic potential of other melanoma cells, our results highlight a novel mechanism whereby cancer cells escape from host immunity and gain metastatic ability by acquiring resistance to oxidative stress responses through the upregulation of GSTA4.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Humans
Interferon-gamma* / genetics
Melanoma* / pathology
Neoplasm Metastasis
Up-Regulation

Substances

Interferon-gamma