Recent advances in capillary gel electrophoresis for the analysis of proteins

Rijul Bhimwal; Richard R Rustandi; Anne Payne; Mohamed Dawod

doi:10.1016/j.chroma.2022.463453

Recent advances in capillary gel electrophoresis for the analysis of proteins

J Chromatogr A. 2022 Oct 25:1682:463453. doi: 10.1016/j.chroma.2022.463453. Epub 2022 Aug 28.

Authors

Rijul Bhimwal¹, Richard R Rustandi², Anne Payne², Mohamed Dawod³

Affiliations

¹ Analytical Research & Development, Merck & Co., Inc., Kenilworth, NJ, USA; The Pennsylvania State University, Huck Institutes of the Life Sciences, University Park, PA, USA.
² Analytical Research & Development, Merck & Co., Inc., Kenilworth, NJ, USA.
³ Analytical Research & Development, Merck & Co., Inc., Kenilworth, NJ, USA; IGM Biosciences, Doylestwon, PA, USA. Electronic address: mohameddawod@gmail.com.

PMID: 36162253
DOI: 10.1016/j.chroma.2022.463453

Abstract

The purpose of this review is to highlight noteworthy advancements in the field of capillary gel electrophoresis for the separation and analysis of proteins from the period of 2015-2021. This review will provide an overview of the historical perspective and principles of the technique, introduce the challenges and limitations commonly faced, and highlight the advancements made to overcome these issues and broaden our knowledge of the method. Finally, applications of capillary gel electrophoresis and future directions for the technique will be presented.

Keywords: CE-SDS; Capillary gel electrophoresis; Electrophoresis; Proteins.

Publication types

Review

MeSH terms

Electrophoresis, Capillary* / methods
Proteins*

Substances

Proteins