Ultra-short T2 components imaging of the whole brain using 3D dual-echo UTE MRI with rosette k-space pattern

Abstract

Purpose: This study aimed to develop a new 3D dual-echo rosette k-space trajectory, specifically designed for UTE MRI applications. The imaging of the ultra-short transverse relaxation time (uT₂ ) of brain was acquired to test the performance of the proposed UTE sequence.

Theory and methods: The rosette trajectory was developed based on rotations of a "petal-like" pattern in the k_x -k_y plane, with oscillated extensions in the k_z -direction for 3D coverage. Five healthy volunteers underwent 10 dual-echo 3D rosette UTE scans with various TEs. Dual-exponential complex model fitting was performed on the magnitude data to separate uT₂ signals, with the output of uT₂ fraction, uT₂ value, and long-T₂ value.

Results: The 3D rosette dual-echo UTE sequence showed better performance than a 3D radial UTE acquisition. More significant signal intensity decay in white matter than gray matter was observed along with the TEs. The white matter regions had higher uT₂ fraction values than gray matter (10.9% ± 1.9% vs. 5.7% ± 2.4%). The uT₂ value was approximately 0.10 ms in white matter .

Conclusion: The higher uT₂ fraction value in white matter compared to gray matter demonstrated the ability of the proposed sequence to capture rapidly decaying signals.

Keywords: k-space; microstructure; non-Cartesian; rosette trajectory; ultra-short echo time.