Regulation of Glial Function by Noncoding RNA in Central Nervous System Disease

Ying Bai; Hui Ren; Liang Bian; You Zhou; Xinping Wang; Zhongli Xiong; Ziqi Liu; Bing Han; Honghong Yao

doi:10.1007/s12264-022-00950-6

Regulation of Glial Function by Noncoding RNA in Central Nervous System Disease

Neurosci Bull. 2023 Mar;39(3):440-452. doi: 10.1007/s12264-022-00950-6. Epub 2022 Sep 26.

Authors

Ying Bai¹, Hui Ren¹, Liang Bian¹, You Zhou¹, Xinping Wang¹, Zhongli Xiong¹, Ziqi Liu¹, Bing Han¹, Honghong Yao^{2

3

4}

Affiliations

¹ Department of Pharmacology, Jiangsu Provincial Key Laboratory, School of Medicine, Southeast University, Nanjing, 210009, China.
² Department of Pharmacology, Jiangsu Provincial Key Laboratory, School of Medicine, Southeast University, Nanjing, 210009, China. yaohh@seu.edu.cn.
³ Co-innovation Center of Neuroregeneration, Nantong University, Nantong, 226001, China. yaohh@seu.edu.cn.
⁴ Institute of Life Sciences, Key Laboratory of Developmental Genes and Human Disease, Southeast University, Nanjing, 210009, China. yaohh@seu.edu.cn.

Abstract

Non-coding RNAs (ncRNAs) are a class of functional RNAs that play critical roles in different diseases. NcRNAs include microRNAs, long ncRNAs, and circular RNAs. They are highly expressed in the brain and are involved in the regulation of physiological and pathophysiological processes of central nervous system (CNS) diseases. Mounting evidence indicates that ncRNAs play key roles in CNS diseases. Further elucidating the mechanisms of ncRNA underlying the process of regulating glial function that may lead to the identification of novel therapeutic targets for CNS diseases.

Keywords: Astrocytes; Circular RNA; Long noncoding RNA; MicroRNA; Microglia; Noncoding RNA; Oligodendrocytes.

Publication types

Review

MeSH terms

Central Nervous System Diseases* / genetics
Humans
MicroRNAs* / genetics
RNA, Circular
RNA, Long Noncoding* / genetics
RNA, Untranslated / genetics

Substances

RNA, Untranslated
MicroRNAs
RNA, Long Noncoding
RNA, Circular