Alternative In Vivo Models to Study Teratoma

Michela Corsini; Stefania Mitola

doi:10.1007/978-1-0716-2703-7_14

Alternative In Vivo Models to Study Teratoma

Methods Mol Biol. 2023:2572:181-189. doi: 10.1007/978-1-0716-2703-7_14.

Authors

Michela Corsini¹, Stefania Mitola²

Affiliations

¹ Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.
² Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy. stefania.mitola@unibs.it.

PMID: 36161417
DOI: 10.1007/978-1-0716-2703-7_14

Abstract

Embryonic stem cells give rise to teratomas when injected in vivo in experimental animal models. The characterization, the manipulation, and the breaking off of this specific characteristic are doubtlessly the last frontier for the applications of stem cells in translational medicine. Moreover, the urgency to adapt to new scientific demands drives the researcher to find alternative and faster models for testing the teratogenic properties of embryonic stem cells. Here, we compare the emerging model of the chick embryo chorioallantoic membrane (CAM) to the murine model, which represents the gold standard procedure for teratogenesis.

Keywords: Chick embryo CAM; ESC differentiation; Embryonic stem cells; Teratoma.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Chick Embryo
Chorioallantoic Membrane
Embryonic Stem Cells
Mice
Teratoma*