Design Strategies of Tumor-Targeted Delivery Systems Based on 2D Nanomaterials

Lin Ding; Minli Liang; Chenchen Li; Xinting Ji; Junfeng Zhang; Weifen Xie; Rui L Reis; Fu-Rong Li; Shuo Gu; Yanli Wang

doi:10.1002/smtd.202200853

Design Strategies of Tumor-Targeted Delivery Systems Based on 2D Nanomaterials

Small Methods. 2022 Nov;6(11):e2200853. doi: 10.1002/smtd.202200853. Epub 2022 Sep 26.

Authors

Lin Ding^{1

2

3

4}, Minli Liang^{2

3

4}, Chenchen Li⁵, Xinting Ji¹, Junfeng Zhang⁵, Weifen Xie⁶, Rui L Reis⁷, Fu-Rong Li^{2

3

4}, Shuo Gu¹, Yanli Wang¹

Affiliations

¹ School of Pharmaceutical Sciences and The First Affiliated Hospital, Hainan Medical University, Haikou, 570228, P. R. China.
² The First Affiliated Hospital (Shenzhen People's Hospital), Southern University of Science and Technology, Shenzhen, 518055, China.
³ Translational Medicine Collaborative Innovation Center, Shenzhen People's Hospital (The First Affiliated Hospital, Southern University of Science and Technology, The Second Clinical Medical College of Jinan University), Shenzhen, Guangdong, 518055, China.
⁴ Guangdong Engineering Technology Research Centerof Stem Cell and Cell Therapy, Shenzhen Key Laboratory of Stem Cell Research and Clinical Transformation, Shenzhen Immune Cell Therapy Public Service Platform, Shenzhen, 518020, China.
⁵ Tumor Precision Targeting Research Center, School of Environmental and Chemical Engineering, Shanghai University, Shanghai, 200444, P. R. China.
⁶ Department of Gastroenterology, Changzheng Hospital, Naval Medical University, Shanghai, 200003, China.
⁷ 3B's Research Group, I3Bs-Research Institute on Biomaterials Biodegradables and Biomimetics, University of Minho, Guimarães, 4805-017, Portugal.

PMID: 36161304
DOI: 10.1002/smtd.202200853

Abstract

Conventional chemotherapy and radiotherapy are nonselective and nonspecific for cell killing, causing serious side effects and threatening the lives of patients. It is of great significance to develop more accurate tumor-targeting therapeutic strategies. Nanotechnology is in a leading position to provide new treatment options for cancer, and it has great potential for selective targeted therapy and controlled drug release. 2D nanomaterials (2D NMs) have broad application prospects in the field of tumor-targeted delivery systems due to their special structure-based functions and excellent optical, electrical, and thermal properties. This review emphasizes the design strategies of tumor-targeted delivery systems based on 2D NMs from three aspects: passive targeting, active targeting, and tumor-microenvironment targeting, in order to promote the rational application of 2D NMs in clinical practice.

Keywords: 2D nanomaterials; delivery systems; tumor-targeting strategies.

Publication types

Review

MeSH terms

Drug Delivery Systems
Humans
Nanostructures* / therapeutic use
Nanotechnology
Neoplasms* / drug therapy
Tumor Microenvironment

Abstract

Publication types

MeSH terms

Grants and funding