Serial assessment of multimodality imaging in anti-leucine-rich glioma-inactivated 1 antibody encephalitis: A case report

Takafumi Wada; Hitoshi Mori; Katsuro Shindo

doi:10.1016/j.ensci.2022.100426

Serial assessment of multimodality imaging in anti-leucine-rich glioma-inactivated 1 antibody encephalitis: A case report

eNeurologicalSci. 2022 Sep 14:29:100426. doi: 10.1016/j.ensci.2022.100426. eCollection 2022 Dec.

Authors

Takafumi Wada¹, Hitoshi Mori¹, Katsuro Shindo¹

Affiliation

¹ Department of Neurology, Kurashiki Central Hospital, 1-1-1 Miwa, Kurashiki/Okayama, 710-8602, Japan.

Abstract

In autoimmune encephalitis, abnormalities of diffusion-weighted imaging (DWI), fluid-attenuated inversion recovery (FLAIR), arterial spin labeling (ASL) in magnetic resonance imaging (MRI), single-photon emission computed tomography (SPECT) and ¹⁸F-fluorodeoxyglucose-positron emission tomography (¹⁸F-FDG-PET) have been reported. However, there are few studies of long-term follow-up of imaging. We report a case of anti-leucine-rich glioma-inactivated 1 antibody encephalitis whose MRI (DWI, FLAIR and ASL), ^99mTcHM-PAO SPECT (PAO-SPECT) and ¹⁸F-FDG-PET were evaluated through the clinical course. ASL, PAO-SPECT and ¹⁸F-FDG-PET consistently showed abnormalities in almost the same area. Serial assessment of these imaging modalities is useful in evaluating disease activity and efficacy of treatment.

Keywords: 18F-FDG-PET; ASL; Anti-LGI1 encephalitis; SPECT.

Publication types

Case Reports