Hepatitis E - epidemiology and clinical course in the largest cohort in the Czech Republic

Matúš Mihalčin; Libuse Husova; Petra Vasickova; Marcel Bena; Petr Husa

doi:10.5114/aoms/152338

Hepatitis E - epidemiology and clinical course in the largest cohort in the Czech Republic

Arch Med Sci. 2022 Aug 30;18(5):1395-1398. doi: 10.5114/aoms/152338. eCollection 2022.

Authors

Matúš Mihalčin^{1

2}, Libuse Husova³, Petra Vasickova⁴, Marcel Bena⁴, Petr Husa^{1

2}

Affiliations

¹ Department of Infectious Diseases, Faculty of Medicine, Masaryk University, Brno, Czech Republic.
² Department of Infectious Diseases, University Hospital Brno, Brno, Czech Republic.
³ Centre of Cardiovascular and Transplant Surgery Brno, Brno, Czech Republic.
⁴ Veterinary Research Institute, Brno, Czech Republic.

Abstract

Introduction: The majority of hepatitis E (HE) reports come from Western Europe. The aim of the study was to describe the typical epidemiological and clinical characteristics of HE in the Czech Republic.

Methods: A retrospective analysis of 173 patients with HE.

Results: At least 90% of cases were autochthonous (HEV-3 genotype). Seventeen patients were treated with ribavirin. Five underwent liver transplants because of fulminant HE. We noted neurological symptomatology in 9 cases. Six patients developed chronic HE.

Conclusions: There is a possibility of severe health complications caused by the hepatitis E virus in the Czech Republic.

Keywords: Czech Republic; Eastern Europe; epidemiology; hepatitis E; hepatitis E virus; therapy; viral zoonosis.