Antiulcerogenic and Antibacterial Effects of Chitosan Derivatives on Experimental Gastric Ulcers in Rats

Leudimar Aires Pereira; Luizângela da Silva Reis; Anderson Nogueira Mendes; Hélio de Barros Fernandes; Daniel Dias Rufino Arcanjo; Adalberto Fortes Rodrigues Júnior; Janete Martins Sousa; Humberto Medeiros Barreto; Jailson de Araújo Santos; Josy Anteveli Osajima; Edson C Silva Filho

doi:10.1155/2022/4743041

Antiulcerogenic and Antibacterial Effects of Chitosan Derivatives on Experimental Gastric Ulcers in Rats

Evid Based Complement Alternat Med. 2022 Sep 16:2022:4743041. doi: 10.1155/2022/4743041. eCollection 2022.

Affiliations

¹ Interdisciplinary Laboratory of Advanced Materials, Postgraduate Program in Materials Science, Federal University of Piauí, CEP: 64049-550, Teresina, Piauí, Brazil.
² Laboratory of Biology, Department of Biology, Universidade Federal do Piauí, 64800-000, Floriano, Piauí, Brazil.
³ Laboratory of Innovation in Science and Technology, Department of Biophysics and Physiology, Federal University of Piauí, CEP: 64049-550, Teresina, Piauí, Brazil.
⁴ Multiprofessional Residence and in Professional Health Areas, Federal University of Piauí, CEP: 64049-550, Teresina, Piauí, Brazil.
⁵ Laboratory of Microbiology Research, Department of Parasitology and Microbiology, Federal University of Piauí, CEP: 64049-550, Teresina, Piauí, Brazil.

Abstract

Gastric ulcer is an injury that develops on the lining of the stomach due to an imbalance between aggressive and defensive agents. Chitosan derivatives demonstrate promising biological activities in accelerating the healing activity of gastric lesions. Thus, this study aimed at investigating the healing activity of gastric lesion, induced by acetic acid (80%), of the chitosan derivative with acetylacetone (Cac) modified with ethylenediamine (Cacen) or diethylenetriamine (Cacdien). The biological activity was determined based on cytotoxicity, antibacterial activity, and gastroprotective activities. The results showed no significant difference in the cytotoxicity, a better antibacterial activity against S. aureus and E. coli, and a positive result on the healing of gastric lesions of the materials (Cac 18.4%, Cacen 55.2%, and Cacdien 68.1%) compared to pure chitosan (50.7%). Therefore, the results indicate that derivatives of chitosan are promising biomaterials for application in the control of lesions on the gastric mucosa.