Clinical Practice Guidelines for Hepatic Arterial Infusion Chemotherapy with a Port System Proposed by the Japanese Society of Interventional Radiology and Japanese Society of Implantable Port Assisted Treatment

Kazuomi Ueshima; Atsushi Komemushi; Takeshi Aramaki; Hideki Iwamoto; Shuntaro Obi; Yozo Sato; Toshihiro Tanaka; Kiyoshi Matsueda; Michihisa Moriguchi; Hiroya Saito; Miyuki Sone; Takuji Yamagami; Yoshitaka Inaba; Masatoshi Kudo; Yasuaki Arai

doi:10.1159/000524893

Clinical Practice Guidelines for Hepatic Arterial Infusion Chemotherapy with a Port System Proposed by the Japanese Society of Interventional Radiology and Japanese Society of Implantable Port Assisted Treatment

Liver Cancer. 2022 May 5;11(5):407-425. doi: 10.1159/000524893. eCollection 2022 Sep.

Authors

Kazuomi Ueshima¹, Atsushi Komemushi², Takeshi Aramaki³, Hideki Iwamoto⁴, Shuntaro Obi⁵, Yozo Sato^{6

7}, Toshihiro Tanaka⁸, Kiyoshi Matsueda⁶, Michihisa Moriguchi⁹, Hiroya Saito¹⁰, Miyuki Sone¹¹, Takuji Yamagami¹², Yoshitaka Inaba⁷, Masatoshi Kudo¹, Yasuaki Arai¹¹

Affiliations

¹ Department of Gastroenterology and Hepatology, Kindai University Faculty of Medicine, Osaka, Japan.
² Department of Radiology, Kansai Medical University Medical Center, Osaka, Japan.
³ Division of Interventional Radiology, Shizuoka Cancer Center, Shizuoka, Japan.
⁴ Division of Gastroenterology/Iwamoto Internal Medicine Clinic, Department of Medicine, Kurume University School of Medicine, Fukuoka, Japan.
⁵ Department of Internal Medicine, Teikyo University Chiba General Medical Center, Chiba, Japan.
⁶ Department of Diagnostic Ultrasound & Interventional Radiology, Cancer Institute Hospital of Japanese Foundation for Cancer Research, Tokyo, Japan.
⁷ Department of Diagnostic and Interventional Radiology, Aichi Cancer Center Hospital, Aichi, Japan.
⁸ Department of Radiology/IVR Center, Nara Medical University, Nara, Japan.
⁹ Department of Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine Graduate School of Medical Science, Kyoto, Japan.
¹⁰ Imaging and IVR Center, Sapporo Higashi Tokushukai Hospital, Hokkaido, Japan.
¹¹ Department of Diagnostic Radiology, National Cancer Center Hospital, Tokyo, Japan.
¹² Department of Diagnostic and Interventional Radiology, Kochi Medical School, Kochi, Japan.

Abstract

Hepatocellular carcinoma is one of the leading causes of cancer-related death both in Japan and globally. In the advanced stage, hepatic arterial infusion chemotherapy (HAIC) is one of the most commonly used treatment options for liver cancer in Japan, and implantation of a catheter system (called a port system) in the body is a treatment method that has evolved mainly in Japan. The Guideline Committee of the Japanese Society of Interventional Radiology and the Japanese Society of Implantable Port Assisted Treatment jointly published clinical practice guidelines for HAIC with a port system to ensure its appropriate and safe performance in Japanese in 2018. We have written an updated English version of the guidelines with the aim of making this treatment widely known to experts globally. In this article, the evidence, method, indication, treatment regimen, and maintenance of the system are summarized.

Keywords: Hepatic arterial infusion chemotherapy; Hepatic arterial infusion chemotherapy with a port system; Hepatocellular carcinoma; Liver cancer; Liver metastases.