LncRNA KCNQ1OT1: Molecular mechanisms and pathogenic roles in human diseases

Fangqi Xia; Yaqi Wang; Mengzhen Xue; Leiqi Zhu; Dengke Jia; Yue Shi; Yan Gao; Luoying Li; Yuanyang Li; Silong Chen; Guangfu Xu; Ding Yuan; Chengfu Yuan

doi:10.1016/j.gendis.2021.07.003

LncRNA KCNQ1OT1: Molecular mechanisms and pathogenic roles in human diseases

Genes Dis. 2021 Aug 16;9(6):1556-1565. doi: 10.1016/j.gendis.2021.07.003. eCollection 2022 Nov.

Authors

Fangqi Xia¹, Yaqi Wang¹, Mengzhen Xue¹, Leiqi Zhu¹, Dengke Jia¹, Yue Shi¹, Yan Gao¹, Luoying Li¹, Yuanyang Li¹, Silong Chen¹, Guangfu Xu¹, Ding Yuan^{1

2}, Chengfu Yuan^{1

2

3}

Affiliations

¹ College of Medical Science, China Three Gorges University, Yichang, Hubei 443002, PR China.
² Third-Grade Pharmacological Laboratory on Chinese Medicine Approved by State Administration of Traditional Chinese Medicine, Medical College of China Three Gorges, Yichang, Hubei 443002, PR China.
³ Hubei Key Laboratory of Tumour Microenvironment and Immunotherapy, China Three Gorges University, Yichang, Hubei 443002, PR China.

Abstract

Long non-coding RNAs (lncRNAs) exhibit a length more than 200 nucleotides and they are characterized by non-coding RNAs (ncRNA) not encoded into proteins. Over the past few years, the role and development of lncRNAs have aroused the rising attention of researchers. To be specific, KCNQ1OT1, the KCNQ1 opposite strand/antisense transcript 1, is clearly classified as a regulatory ncRNA. KCNQ1OT1 is capable of interacting with miRNAs, RNAs and proteins, thereby affecting gene expression and various cell functions (e.g., cell proliferation, migration, epithelial-mesenchymal transition (EMT), apoptosis, viability, autophagy and inflammation). KCNQ1OT1 is dysregulated in a wide range of human diseases (e.g., cardiovascular disease, cancer, diabetes, osteoarthritis, osteoporosis and cataract), and it is speculated to act as a therapeutic target for treating various human diseases. On the whole, this review aims to explore the biological functions, underlying mechanisms and pathogenic roles of KCNQ1OT1 in human diseases.

Keywords: Cell functions; Human diseases; KCNQ1OT1; Long non–coding RNA; Regulatory ncRNA.

Publication types

Review