The role of long non-coding RNA ANRIL in the development of atherosclerosis

Ilgiz Gareev; Valentin Kudriashov; Albert Sufianov; Sema Begliarzade; Tatiana Ilyasova; Yanchao Liang; Ozal Beylerli

doi:10.1016/j.ncrna.2022.09.002

The role of long non-coding RNA ANRIL in the development of atherosclerosis

Noncoding RNA Res. 2022 Sep 6;7(4):212-216. doi: 10.1016/j.ncrna.2022.09.002. eCollection 2022 Dec.

Authors

Ilgiz Gareev¹, Valentin Kudriashov², Albert Sufianov^{1

3}, Sema Begliarzade⁴, Tatiana Ilyasova⁵, Yanchao Liang⁶, Ozal Beylerli¹

Affiliations

¹ Educational and Scientific Institute of Neurosurgery, Рeoples' Friendship University of Russia (RUDN University), 6 Miklukho-Maklaya St, Moscow, 117198, Russian Federation.
² Gastric Cancer Center, West China Hospital of Sichuan University, China.
³ Department of Neurosurgery, Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia.
⁴ Republican Clinical Perinatal Center, Republic of Bashkortostan, 450106, Russia.
⁵ Department of Internal Diseases, Bashkir State Medical University, Republic of Bashkortostan, Ufa, 450008, Russia.
⁶ Department of Neurosurgery, The First Affiliated Hospital of Harbin Medical University, Harbin, 150001, China.

Abstract

Atherosclerosis is an important pathological basis of coronary heart disease, and the antisense non-coding RNA in the INK4 locus (ANRIL) is located in the genetically susceptible segment with the strongest correlation with it - the short arm 2 region 1 of chromosome 9 (Chr9p21). ANRIL can produce linear, circular and other transcripts through different transcriptional splicing methods, which can regulate the proliferation and apoptosis of related cells and closely related to the development of atherosclerotic plaques. Linear ANRIL can regulate proliferation of vascular smooth muscle cells (VSMCs) in plaques by chromatin modification, as well as affecting on proliferation and the apoptosis of macrophages at the transcriptional level; circular ANRIL can affect on proliferation and apoptosis of VSMCs by chromatin modification as well as interfering with rRNA maturation. In this review we describe the evolutionary characteristics of ANRIL, the formation and structure of transcripts, and the mechanism by which each transcript regulates the proliferation and apoptosis of vascular cells and then participates in atherosclerosis.

Keywords: ANRIL; Apoptosis; Atherosclerosis; Cell proliferation; Long non-coding RNA.

Publication types

Review