Increased circulating T follicular helper 13 subset correlates with high IgE levels in pediatric allergic asthma

Xiao Tong; Chaojiao Guan; Tuo Ji; Cheng Cao; Junfeng Jiang; Min Liu; Qin Guo; Pengcheng Zhou; Fang Gong

doi:10.1002/eji.202250076

Increased circulating T follicular helper 13 subset correlates with high IgE levels in pediatric allergic asthma

Eur J Immunol. 2022 Dec;52(12):2010-2012. doi: 10.1002/eji.202250076. Epub 2022 Oct 26.

Authors

Xiao Tong¹, Chaojiao Guan^{1

2}, Tuo Ji^{3

4}, Cheng Cao^{4

5}, Junfeng Jiang^{4

5}, Min Liu⁴, Qin Guo⁴, Pengcheng Zhou^{4

6}, Fang Gong⁴

Affiliations

¹ Department of Pediatrics, Affiliated Hospital of Jiangnan University, Wuxi, Jiangsu, China.
² Department of Pediatrics, The First People's Hospital of Huzhou, Huzhou, Zhejiang, China.
³ Department of Central Laboratory, Cancer Hospital of Lianyungang, Lianyungang, Jiangsu, China.
⁴ Department of Laboratory Medicine, Affiliated Hospital of Jiangnan University, Wuxi, Jiangsu, China.
⁵ Wuxi School of Medicine, Jiangnan University, Wuxi, Jiangsu, China.
⁶ The John Curtin School of Medical Research, The Australian National University, Canberra, ACT, Australia.

PMID: 36153835
DOI: 10.1002/eji.202250076

Abstract

We found an elevation of circulating TFH13 cell subset in asthmatic children and the frequency of TFH13 cells positively correlated with the plasma dust mite-specific IgE levels. These results indicated that TFH13 cell subset may be responsible for the immunopathogenesis of excessive IgE accumulation in children with allergic asthma.

Keywords: IL-13; IgE; TFH13; pediatric allergic asthma; peripheral blood.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Child
Humans
T-Lymphocytes, Helper-Inducer*