Approach to Familial Predisposition to Colorectal Cancer

Veroushka Ballester; Marcia Cruz-Correa

doi:10.1016/j.gtc.2022.06.001

Approach to Familial Predisposition to Colorectal Cancer

Gastroenterol Clin North Am. 2022 Sep;51(3):593-607. doi: 10.1016/j.gtc.2022.06.001. Epub 2022 Aug 30.

Authors

Veroushka Ballester¹, Marcia Cruz-Correa²

Affiliations

¹ University of Puerto Rico Comprehensive Cancer Center, PMB 711 89 De Diego, De Diego Avenue 105, Rio Piedras, PR 00927-6346, USA; Department of Medicine, Biochemistry and Surgery, University of Puerto Rico Medical Sciences Campus, PO BOX 365067, San Juan, PR 00936, USA.
² University of Puerto Rico Comprehensive Cancer Center, PMB 711 89 De Diego, De Diego Avenue 105, Rio Piedras, PR 00927-6346, USA; Department of Medicine, Biochemistry and Surgery, University of Puerto Rico Medical Sciences Campus, PO BOX 365067, San Juan, PR 00936, USA. Electronic address: marcia.cruz1@upr.edu.

PMID: 36153112
DOI: 10.1016/j.gtc.2022.06.001

Abstract

The traditional approach of one-size-fits-all for colorectal cancer has been replaced by personalized interventions to an individual's unique genetic, molecular, and environmental profile, seeking to identify high-risk individuals who would benefit from individualized screening and surveillance. This change in approach is due, in part, to emerging technologies, such as next-generation DNA sequencing.

Keywords: Colorectal cancer; Familial adenomatous polyposis; Familial colorectal cancer; Hereditary colorectal cancer syndromes; Lynch syndrome; Nonpolyposis syndromes; Polyposis syndromes.

Publication types

Review

MeSH terms

Adenomatous Polyposis Coli* / genetics
Colorectal Neoplasms* / genetics
Colorectal Neoplasms* / prevention & control
Colorectal Neoplasms, Hereditary Nonpolyposis* / genetics
Genetic Predisposition to Disease
Genetic Testing
Humans
Mass Screening