The O-GlcNAcylation and its promotion to hepatocellular carcinoma

Jie Zhang; Min Xun; Chaojie Li; Yuping Chen

doi:10.1016/j.bbcan.2022.188806

The O-GlcNAcylation and its promotion to hepatocellular carcinoma

Biochim Biophys Acta Rev Cancer. 2022 Nov;1877(6):188806. doi: 10.1016/j.bbcan.2022.188806. Epub 2022 Sep 21.

Authors

Jie Zhang¹, Min Xun¹, Chaojie Li¹, Yuping Chen²

Affiliations

¹ Institute of Pharmacy & Pharmacology, School of Pharmaceutical Science, University of South China, Hengyang 410001, China.
² Institute of Pharmacy & Pharmacology, School of Pharmaceutical Science, University of South China, Hengyang 410001, China. Electronic address: 2017001009@usc.edu.cn.

PMID: 36152903
DOI: 10.1016/j.bbcan.2022.188806

Abstract

O-GlcNAcylation is a posttranslational modification that attaches O-linked β-N-acetylglucosamine (O-GlcNAc) to the serine and threonine residues of proteins. Such a glycosylation would alter the activities, stabilities, and interactions of target proteins that are functional in a wide range of biological processes and diseases. Accumulating evidence indicates that O-GlcNAcylation is tightly associated with hepatocellular carcinoma (HCC) in its onset, growth, invasion and metastasis, drug resistance, and stemness. Here we summarize the discoveries of the role of O-GlcNAcylation in HCC and its function mechanism, aiming to deepen our understanding of HCC pathology, generate more biomarkers for its diagnosis and prognosis, and offer novel molecular targets for its treatment.

Keywords: Hepatocellular carcinoma; Hexosamine biosynthesis; Metabolic reprogramming; O-GlcNAcylation.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Acetylglucosamine / metabolism
Carcinoma, Hepatocellular* / genetics
Glycosylation
Humans
Liver Neoplasms*
Protein Processing, Post-Translational

Substances

Acetylglucosamine