Do bioactive 8-hydroxyquinolines oxidovanadium(IV) and (V) complexes inhibit the growth of M. smegmatis?

Gonzalo Scalese; Zeyad Arhouma; Kateryna Kostenkova; Leticia Pérez-Díaz; Dean C Crick; Dinorah Gambino; Debbie C Crans

doi:10.1016/j.jinorgbio.2022.111984

Do bioactive 8-hydroxyquinolines oxidovanadium(IV) and (V) complexes inhibit the growth of M. smegmatis?

J Inorg Biochem. 2022 Dec:237:111984. doi: 10.1016/j.jinorgbio.2022.111984. Epub 2022 Sep 3.

Authors

Gonzalo Scalese¹, Zeyad Arhouma², Kateryna Kostenkova³, Leticia Pérez-Díaz⁴, Dean C Crick⁵, Dinorah Gambino⁶, Debbie C Crans⁷

Affiliations

¹ Área Química Inorgánica, Facultad de Química, Universidad de la República, 11800 Montevideo, Uruguay; Department of Chemistry, Colorado State University, Fort Collins, CO 80523, United States.
² Department of Chemistry, Colorado State University, Fort Collins, CO 80523, United States; Cell and Molecular Biology Program, Colorado State University, Fort Collins, CO 80523, United States.
³ Department of Chemistry, Colorado State University, Fort Collins, CO 80523, United States.
⁴ Laboratorio de Interacciones Moleculares, Facultad de Ciencias, Universidad de la República, 11400 Montevideo, Uruguay.
⁵ Cell and Molecular Biology Program, Colorado State University, Fort Collins, CO 80523, United States; Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology,Colorado State University, Fort Collins, CO 80523, United States.
⁶ Área Química Inorgánica, Facultad de Química, Universidad de la República, 11800 Montevideo, Uruguay. Electronic address: dgambino@fq.edu.uy.
⁷ Department of Chemistry, Colorado State University, Fort Collins, CO 80523, United States; Cell and Molecular Biology Program, Colorado State University, Fort Collins, CO 80523, United States. Electronic address: Debbie.Crans@colostate.edu.

PMID: 36152468
DOI: 10.1016/j.jinorgbio.2022.111984

Abstract

The antiproliferative effects of four series of V^IVO- and V^VO-based compounds containing 8-hydroxyquinoline ligands on the bacterium Mycolicibacterium smegmatis (M. smeg) were investigated. The effects on M. smeg were compared to the antiproliferative effects on the protozoan parasite Trypanosoma cruzi (T. cruzi), the causative agent for Chagas disease. In this study, we investigate the speciation of these compounds under physiological conditions as well as the antiproliferative effects on the bacterium M. smeg. We find that the complexes are more stable the less H₂O is present, and that the stability increases in lipid-like environments. Only one heteroleptic complex and two homoleptic complexes were found to show similar antiproliferative effects on M. smeg as reported for T. cruzi so the responses generally observed by M.smeg. is less than observed by the pathogen. In summary, we find that M. smeg is more sensitive to the detailed structure of the V-complex but overall these complexes are less effective against M. smeg compared to T. cruzi.

Keywords: 8-hydroxyquinolines; M. smegmatis; Oxidovanadium compounds; Speciation chemistry, coordination complexes; Vanadium.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Chagas Disease*
Coordination Complexes* / chemistry
Coordination Complexes* / pharmacology
Humans
Ligands
Oxyquinoline / pharmacology
Trypanosoma cruzi*
Vanadium / chemistry

Substances

Vanadium
Oxyquinoline
Ligands
Coordination Complexes