Applications of Peptide Microarrays in Autoantibody, Infection, and Cancer Detection

Carsten Grötzinger

doi:10.1007/978-1-0716-2732-7_1

Applications of Peptide Microarrays in Autoantibody, Infection, and Cancer Detection

Methods Mol Biol. 2023:2578:1-15. doi: 10.1007/978-1-0716-2732-7_1.

Author

Carsten Grötzinger^{1

2}

Affiliations

¹ Department of Hepatology and Gastroenterology, Charité - Universitätsmedizin Berlin, Berlin, Germany. carsten.groetzinger@charite.de.
² Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany. carsten.groetzinger@charite.de.

PMID: 36152276
DOI: 10.1007/978-1-0716-2732-7_1

Abstract

The diversity of the antigen-specific humoral immune response reflects the interaction of the immune system with pathogens and autoantigens. Peptide microarray analysis opens up new perspectives for the use of antibodies as diagnostic biomarkers and provides unique access to a more differentiated view on humoral responses to disease. This review focuses on the latest applications of peptide microarrays for the serologic medical diagnosis of autoimmunity, infectious diseases (including COVID-19), and cancer.

Keywords: Autoantibody; Cancer; Infection; Peptide microarray; Serodiagnostics.

Publication types

Review

MeSH terms

Autoantibodies / analysis
Autoantigens
Biomarkers
COVID-19* / diagnosis
Humans
Microarray Analysis
Neoplasms* / diagnosis
Peptides
Protein Array Analysis

Substances

Autoantibodies
Autoantigens
Biomarkers
Peptides